Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 5/20 | 0.70 |
| ▸ | PPARG | P37231 | 4/20 | 0.64 |
| ▸ | CTSS | P25774 | 4/20 | 0.60 |
| ▸ | ACE | P12821 | 1/20 | 0.51 |
| ▸ | KLK7 | P49862 | 2/20 | 0.51 |
| ▸ | KLK5 | Q9Y337 | 2/20 | 0.51 |
| ▸ | PTPN1 | P18031 | 4/20 | 0.48 |
| ▸ | CDC25B | P30305 | 4/20 | 0.48 |
| ▸ | PTPN2 | P17706 | 3/20 | 0.48 |
| ▸ | CDC25A | P30304 | 2/20 | 0.48 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.48 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.48 |
| ▸ | PPARD | Q03181 | 2/20 | 0.47 |
| ▸ | CTSK | P43235 | 2/20 | 0.47 |
| ▸ | CTSL | P07711 | 1/20 | 0.47 |
| ▸ | CTSB | P07858 | 1/20 | 0.47 |
| ▸ | REN | P00797 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5710546 | 0.91 | PPARA (0.61) | PPARAPPARGCTSSKLK7KLK5 | |
| SCHEMBL6043892 | 0.91 | PPARA (0.61) | PPARAPPARGCTSSKLK7KLK5 | |
| SCHEMBL6042808 | 0.91 | PPARA (0.61) | PPARAPPARGCTSSKLK7KLK5 | |
| SCHEMBL8905959 | 0.89 | PPARA (0.59) | PPARAPPARGCTSSKLK7KLK5 | |
| SCHEMBL5349842 | 0.89 | PPARA (0.59) | PPARAPPARGCTSSKLK7KLK5 | |
| SCHEMBL8906370 | 0.89 | PPARA (0.59) | PPARAPPARGCTSSKLK7KLK5 | |
| SCHEMBL1132901 | 0.87 | PPARA (0.90) | PPARAPPARGCTSSACEKLK7 | |
| SCHEMBL828674 | 0.87 | PPARA (0.90) | PPARAPPARGCTSSACEKLK7 | |
| SCHEMBL17051 | 0.87 | PPARA (0.90) | PPARAPPARGCTSSACEKLK7 | |
| SCHEMBL22981235 | 0.86 | PPARA (0.73) | PPARAPPARGCTSSACEKLK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8084485-B2 | 6-(aminoalkyl)indazoles | VITAE PHARMACEUTICALS, INC. (US) | 2011-12-27 | — | — | US | disclosed |
| US-20100331287-A1 | 6-(Aminoalkyl)Indazoles | VITAE PHARMACEUTICALS, INC. | 2010-12-30 | — | — | US | disclosed |
| US-20080058320-A1 | Organic Compounds | NOVARTIS AG (CH) | 2008-03-06 | — | — | US | disclosed |
| WO-2007120523-A2 | 6-(AMINOALKYL)INDAZOLES | VITAE PHARMACEUTICALS, INC. (US) | 2007-10-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100331287-A1 | 6-(Aminoalkyl)Indazoles | REN, AGTR1, AGTR2 | PPARA 1275/4885PPARG 1296/4885CTSS 2208/4885 |
| US-20080058320-A1 | Organic Compounds | REN, AGTR1, ADH1C | PPARA 3272/4885PPARG 2474/4885CTSS 1144/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.