SCHEMBL379494

SCHEMBL379494

c1cc2c(c(Nc3cccc4c3NCCC4)c1)NCCC2

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SRC P12931 1/20 0.47
AKT1 P31749 1/20 0.38
MEN1 O00255 1/20 0.35
KCNK2 O95069 1/20 0.35
KCNK10 P57789 1/20 0.35
KMT2A Q03164 1/20 0.35
KCNK18 Q7Z418 1/20 0.35
TDP1 Q9NUW8 1/20 0.35
SLC13A5 Q86YT5 1/20 0.34
TSHR P16473 1/20 0.34
HTT P42858 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
NPSR1 Q6W5P4 1/20 0.34
KDM4E B2RXH2 2/20 0.33
NPC1 O15118 1/20 0.33
ALDH1A1 P00352 1/20 0.33
MAPT P10636 1/20 0.33
HPGD P15428 1/20 0.33
ALOX12 P18054 1/20 0.33
ADORA2A P29274 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28028253 0.85 SRC (0.45) SRCAKT1MEN1KMT2ASLC13A5
SCHEMBL379547 0.82 KDM4E (0.41) SRCAKT1TDP1HTTKDM4E
SCHEMBL24429192 0.81 SRC (0.46) SRCAKT1MEN1KMT2ASLC13A5
SCHEMBL1010818 0.81 TRPV1 (0.40) SRCAKT1MEN1KMT2AHTT
SCHEMBL1009675 0.81 ALDH1A1 (0.41) SRCAKT1MEN1KMT2ASMN1; SMN2
SCHEMBL5051442 0.79 SRC (0.47) SRCAKT1MEN1KMT2AKDM4E
SCHEMBL1010061 0.77 HPGD (0.39) MEN1KMT2ASLC13A5HTTSMN1; SMN2
SCHEMBL29661346 0.77 INSR (0.39) SRCAKT1
SCHEMBL24327013 0.77 INSR (0.39) SRCAKT1
SCHEMBL6984840 0.75 KDM4E (0.51) SRCAKT1MEN1KMT2AHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1801105-B1 Dibenzo[b]perhydroheterocyclic amines and lubricating oil compositions CHEVRON ORONITE CO (US) 2012-01-25 EP claimed
EP-1801105-B1 Dibenzo[b]perhydroheterocyclic amines and lubricating oil compositions CHEVRON ORONITE CO (US) 2012-01-25 EP disclosed
EP-1801105-B1 Dibenzo[b]perhydroheterocyclic amines and lubricating oil compositions CHEVRON ORONITE CO (US) 2012-01-25 EP disclosed
US-7285518-B2 Dibenzo[b]perhydroheterocyclic amines and lubricating oil compositions CHEVRON ORONITE COMPANY LLC (US) 2007-10-23 US disclosed
US-7285518-B2 Dibenzo[b]perhydroheterocyclic amines and lubricating oil compositions CHEVRON ORONITE COMPANY LLC (US) 2007-10-23 US disclosed
US-7285518-B2 Dibenzo[b]perhydroheterocyclic amines and lubricating oil compositions CHEVRON ORONITE COMPANY LLC (US) 2007-10-23 US disclosed
EP-1801105-A1 Dibenzo[b]perhydroheterocyclic amines and lubricating oil compositions Chevron Oronite Company LLC (US) 2007-06-27 EP disclosed
EP-1801105-A1 Dibenzo[b]perhydroheterocyclic amines and lubricating oil compositions Chevron Oronite Company LLC (US) 2007-06-27 EP disclosed
US-20070142245-A1 Dibenzo[b]perhydroheterocyclic amines and lubricating oil compositions CHEVRON ORONITE COMPANY LLC 2007-06-21 US disclosed
US-20070142245-A1 Dibenzo[b]perhydroheterocyclic amines and lubricating oil compositions CHEVRON ORONITE COMPANY LLC 2007-06-21 US disclosed
US-20070142245-A1 Dibenzo[b]perhydroheterocyclic amines and lubricating oil compositions CHEVRON ORONITE COMPANY LLC 2007-06-21 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070142245-A1 Dibenzo[b]perhydroheterocyclic amines and lubricating oil compositions ALOX12, ALOX15B, HRH1 SRC 3571/4885AKT1 2902/4885MEN1 3543/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.