Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Diphenylether. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 7/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | NPY5R | Q15761 | 4/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | CRHBP | P24387 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.38 |
| ▸ | BAX | Q07812 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Diphenylether SCHEMBL8049569 | 0.87 | LMNA (0.53) | LTA4HLMNANPY5RTSHRNR1H2 | |
| Diphenylether SCHEMBL50452 | 0.87 | LMNA (0.57) | LTA4HLMNANPY5RTSHRHPGD | |
| Diphenylether SCHEMBL5067162 | 0.85 | LTA4H (0.53) | LTA4HLMNATSHRNPC1HPGD | |
| Diphenylether SCHEMBL28593325 | 0.85 | LMNA (0.55) | LTA4HLMNANPY5RTSHRRAB9A | |
| Phenetole SCHEMBL12970958 | 0.84 | LMNA (0.56) | LTA4HLMNANPC1HPGDRAB9A | |
| Diphenylether SCHEMBL7865304 | 0.84 | LMNA (0.47) | LTA4HLMNANPY5RTSHRRAB9A | |
| Biphenyl SCHEMBL2505116 | 0.82 | LMNA (0.42) | LMNATSHRSMN1; SMN2 | |
| Diphenylether SCHEMBL7456599 | 0.81 | LTA4H (0.67) | LTA4HLMNATSHRNPC1HPGD | |
| Benzene SCHEMBL2865296 | 0.81 | TDP1 (0.53) | LMNATSHRHSD17B10SMN1; SMN2 | |
| Diphenylether SCHEMBL6560849 | 0.81 | NPY5R (0.49) | LTA4HLMNANPY5RNPC1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100233387-A1 | INK FOR MAKING COLOR FILTER AND COLOR FILTER MADE THEREOF | ICF TECHNOLOGY LIMITED. (US) | 2010-09-16 | — | — | US | disclosed |