Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Diphenylether. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPY5R | Q15761 | 5/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | LTA4H | P09960 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | CRHBP | P24387 | 1/20 | 0.44 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Diphenylether SCHEMBL896711 | 0.89 | NPY5R (0.51) | NPY5RLMNASRD5A2PTGS1KDM4E | |
| Diphenylether SCHEMBL8049569 | 0.89 | LMNA (0.53) | NPY5RLMNAPTGS1KDM4ELTA4H | |
| Diphenylether SCHEMBL50452 | 0.89 | LMNA (0.57) | NPY5RLMNAPTGS1KDM4ELTA4H | |
| Diphenylether SCHEMBL28593325 | 0.87 | LMNA (0.55) | NPY5RLMNAPTGS1KDM4ELTA4H | |
| Diphenylether SCHEMBL8533552 | 0.87 | LTA4H (0.57) | SRD5A2FFAR1LTA4HRAB9ANPC1 | |
| Diphenylether SCHEMBL6560478 | 0.85 | FFAR1 (0.52) | SRD5A2FFAR1LTA4HRAB9ANPC1 | |
| Diphenylether SCHEMBL23494789 | 0.83 | TGM2 (0.47) | NPY5RLMNASRD5A2PTGS1KDM4E | |
| Diphenylether SCHEMBL7197965 | 0.83 | FFAR1 (0.53) | SRD5A2FFAR1LTA4HRAB9ANPC1 | |
| Diphenylether SCHEMBL3797141 | 0.81 | LTA4H (0.47) | NPY5RLMNAPTGS1KDM4ELTA4H | |
| Diphenylether SCHEMBL7865304 | 0.79 | LMNA (0.47) | NPY5RLMNAPTGS1KDM4ELTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0735403-B1 | Liquid crystal orienting agent | JSR CORP (JP) | 2004-03-17 | — | — | EP | disclosed |
| US-5700860-A | Liquid crystal orienting agent | JAPAN SYNTHETIC RUBBER CO., LTD. (JP) | 1997-12-23 | — | — | US | disclosed |
| EP-0735403-A1 | Liquid crystal orienting agent | JAPAN SYNTHETIC RUBBER CO., LTD. (JP) | 1996-10-02 | — | — | EP | disclosed |