Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 4/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.35 |
| ▸ | NOS3 | P29474 | 1/20 | 0.35 |
| ▸ | NOS1 | P29475 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4765934 | 0.80 | MGLL (0.40) | ALDH1A1LMNAKDM4E | |
| SCHEMBL2879390 | 0.79 | RECQL (0.42) | HRH3KMT2AMEN1HTTGAA | |
| SCHEMBL2884746 | 0.79 | HRH3 (0.51) | HRH3HDAC1HDAC6KMT2A | |
| SCHEMBL4764592 | 0.76 | HRH3 (0.54) | HRH3HDAC1HDAC6 | |
| SCHEMBL4791769 | 0.75 | HRH3 (0.38) | HRH3HDAC1HDAC6KMT2AMEN1 | |
| SCHEMBL4792764 | 0.75 | ADAM17 (0.46) | HRH3KMT2AMEN1HTTMAPT | |
| SCHEMBL3841290 | 0.74 | ALDH1A1 (0.47) | HTTGAAALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL4724233 | 0.74 | HPGD (0.54) | HDAC1HDAC6KMT2AGAAALDH1A1 | |
| SCHEMBL4792689 | 0.73 | CDK9 (0.44) | HRH3NPSR1HTTALDH1A1SMN1; SMN2 | |
| SCHEMBL4793189 | 0.73 | HRH3 (0.40) | HRH3HTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010133544-A1 | PIPERAZINE AND AMINOPYRROLIDINE COMPOUNDS AS HISTAMINE H3 RECEPTOR ANTAGONISTS | EVOTEC AG (DE) | 2010-11-25 | — | — | WO | disclosed |