Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 7/20 | 0.40 |
| ▸ | PRPS1 | P60891 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | CDK9 | P50750 | 5/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | FLT3 | P36888 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4792689 | 0.93 | CDK9 (0.44) | HRH3PRPS1CDK9IDO1KCNH2 | |
| SCHEMBL4790266 | 0.91 | CDK9 (0.42) | HRH3PRPS1CDK9IDO1FLT3 | |
| SCHEMBL4790952 | 0.83 | HRH3 (0.42) | HRH3PPARGKCNH2 | |
| SCHEMBL4791769 | 0.80 | HRH3 (0.38) | HRH3CDK9IDO1KCNH2 | |
| SCHEMBL4761940 | 0.80 | HRH3 (0.42) | HRH3CDK9KCNH2 | |
| SCHEMBL2884746 | 0.76 | HRH3 (0.51) | HRH3 | |
| SCHEMBL4790887 | 0.76 | L3MBTL1 (0.36) | KCNH2SMN1; SMN2 | |
| SCHEMBL3839546 | 0.74 | KDM4E (0.41) | MAPK1HTT | |
| SCHEMBL3797395 | 0.73 | HRH3 (0.46) | HRH3HTTSMN1; SMN2 | |
| SCHEMBL4792357 | 0.73 | PRPS1 (0.40) | PRPS1CDK9KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1994022-A2 | N-SUBSTITUTED-AZACYCLYLAMINES AS HISTAMINE-3 ANTAGONISTS | Wyeth a Corporation of the State of Delaware (US) | 2008-11-26 | — | — | EP | disclosed |
| WO-2007108936-A2 | N-SUBSTITUTED-AZACYCLYLAMINES AS HISTAMINE-3 ANTAGONISTS | WYETH (US) | 2007-09-27 | — | — | WO | disclosed |