Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A known ✓ | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | ESR1 | P03372 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HCAR2 | Q8TDS4 | 3/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL3797445 | 1.00 | KMT2A (0.41) | KMT2ATSHRALDH1A1ESR1HSD17B10 | |
| Fumaric Acid SCHEMBL3796830 | 0.90 | TSHR (0.48) | KMT2ATSHRALDH1A1ESR1HSD17B10 | |
| Maleic Acid SCHEMBL3796821 | 0.90 | TSHR (0.48) | KMT2ATSHRALDH1A1ESR1HSD17B10 | |
| Fumaric Acid SCHEMBL3796831 | 0.90 | TSHR (0.48) | KMT2ATSHRALDH1A1ESR1HSD17B10 | |
| SCHEMBL20073661 | 0.82 | TSHR (0.51) | KMT2ATSHRALDH1A1ESR1HSD17B10 | |
| SCHEMBL3797450 | 0.76 | HCAR2 (0.33) | HCAR2 | |
| SCHEMBL13130571 | 0.75 | TSHR (0.39) | KMT2ATSHRALDH1A1ESR1HSD17B10 | |
| SCHEMBL14706863 | 0.75 | TSHR (0.45) | KMT2ATSHRALDH1A1ESR1HSD17B10 | |
| SCHEMBL15850409 | 0.75 | TSHR (0.45) | KMT2ATSHRALDH1A1ESR1HSD17B10 | |
| SCHEMBL25699072 | 0.70 | KMT2A (0.41) | KMT2ATSHRALDH1A1ESR1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1893169-A2 | STABILIZED BODY CARE PRODUCTS, HOUSEHOLD PRODUCTS, TEXTILES AND FABRICS CONTAINING STERICALLY HINDERED AMINE SALT COMPOUND | Ciba Specialty Chemicals Holding Inc. (CH) | 2008-03-05 | — | — | EP | claimed |
| WO-2006122889-A2 | STABILIZED BODY CARE PRODUCTS, HOUSEHOLD PRODUCTS, TEXTILES AND FABRICS CONTAINING STERICALLY HINDERED AMINE SALT COMPOUNDS | CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) | 2006-11-23 | — | — | WO | claimed |
| WO-2006122888-A1 | INK JET INK AND RECORDING MATERIAL | CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) | 2006-11-23 | — | — | WO | claimed |
| US-20060264345-A1 | Stabilized body care products, household products, textiles and fabrics | BASF SE (DE) | 2006-11-23 | — | — | US | claimed |
| EP-2207522-A2 | BODY-CARE AND HOUSEHOLD PRODUCTS AND COMPOSITIONS COMPRISING SPECIFIC SULFUR-CONTAINING COMPOUNDS | BASF SE (DE) | 2010-07-21 | — | — | EP | disclosed |
| WO-2009047150-A2 | BODY-CARE AND HOUSEHOLD PRODUCTS AND COMPOSITIONS COMPRISING SPECIFIC SULFUR-CONTAINING COMPOUNDS | BASF SE (CH) | 2009-04-16 | — | — | WO | disclosed |
| EP-1893169-A2 | STABILIZED BODY CARE PRODUCTS, HOUSEHOLD PRODUCTS, TEXTILES AND FABRICS CONTAINING STERICALLY HINDERED AMINE SALT COMPOUND | Ciba Specialty Chemicals Holding Inc. (CH) | 2008-03-05 | — | — | EP | disclosed |
| WO-2006122888-A1 | INK JET INK AND RECORDING MATERIAL | CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) | 2006-11-23 | — | — | WO | disclosed |
| WO-2006122889-A2 | STABILIZED BODY CARE PRODUCTS, HOUSEHOLD PRODUCTS, TEXTILES AND FABRICS CONTAINING STERICALLY HINDERED AMINE SALT COMPOUNDS | CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) | 2006-11-23 | — | — | WO | disclosed |
| US-20060264345-A1 | Stabilized body care products, household products, textiles and fabrics | BASF SE (DE) | 2006-11-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060264345-A1 | Stabilized body care products, household products, textiles and fabrics | DSC1, CUTA, DSG1 | KMT2A 1031/4885MEN1 1581/4885TSHR 1283/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.