Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A known ✓ | Q03164 | 2/20 | 0.48 |
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | ESR1 | P03372 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL3796831 | 1.00 | TSHR (0.48) | TSHRKMT2AALDH1A1ESR1HSD17B10 | |
| Maleic Acid SCHEMBL3796821 | 1.00 | TSHR (0.48) | TSHRKMT2AALDH1A1ESR1HSD17B10 | |
| SCHEMBL20073661 | 0.91 | TSHR (0.51) | TSHRKMT2AALDH1A1ESR1HSD17B10 | |
| Maleic Acid SCHEMBL3797445 | 0.90 | KMT2A (0.41) | TSHRKMT2AALDH1A1ESR1HSD17B10 | |
| Fumaric Acid SCHEMBL3797452 | 0.90 | KMT2A (0.41) | TSHRKMT2AALDH1A1ESR1HSD17B10 | |
| SCHEMBL13130571 | 0.80 | TSHR (0.39) | TSHRKMT2AALDH1A1ESR1HSD17B10 | |
| SCHEMBL3473691 | 0.77 | TSHR (0.41) | TSHRKMT2AALDH1A1ESR1HSD17B10 | |
| SCHEMBL14706863 | 0.74 | TSHR (0.45) | TSHRKMT2AALDH1A1ESR1HSD17B10 | |
| SCHEMBL15850409 | 0.74 | TSHR (0.45) | TSHRKMT2AALDH1A1ESR1HSD17B10 | |
| SCHEMBL7479511 | 0.74 | NAAA (0.46) | TSHRKMT2AALDH1A1ESR1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080253981-A1 | Stabilized body care products, household products, textiles and fabrics | LUPIA JOSEPH A | 2008-10-16 | — | — | US | claimed |
| US-20080250572-A1 | Stabilized body care products, household products, textiles and fabrics | LUPIA JOSEPH A | 2008-10-16 | — | — | US | claimed |
| US-20080221332-A1 | Hindered Amine salt compounds | WOOD MARVIN G | 2008-09-11 | — | — | US | claimed |
| US-20060040836-A1 | Stabilized body care products, household products, textiles and fabrics | CIBA CORPORATION | 2006-02-23 | — | — | US | claimed |
| US-20050234151-A1 | Ink jet ink and recording material | CIBA SPECIALTY CHEMICALS CORP. | 2005-10-20 | — | — | US | claimed |
| WO-2005092992-A1 | INK JET INK AND RECORDING MATERIAL | CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) | 2005-10-06 | — | — | WO | claimed |
| EP-2207522-B1 | PERSONAL CARE AND HOUSEHOLD PRODUCT COMPOSITIONS COMPRISING SPECIFIC SULFUR CONTAINING STABILISER COMPOUNDS | BASF SE (DE) | 2019-11-06 | — | — | EP | disclosed |
| EP-2207522-A2 | BODY-CARE AND HOUSEHOLD PRODUCTS AND COMPOSITIONS COMPRISING SPECIFIC SULFUR-CONTAINING COMPOUNDS | BASF SE (DE) | 2010-07-21 | — | — | EP | disclosed |
| US-7632795-B2 | Stabilized body care products, household products, textiles and fabrics | CIBA SPECIALTY CHEMICALS CORPORATION (US) | 2009-12-15 | — | — | US | disclosed |
| US-7615503-B2 | Stabilized body care products, household products, textiles and fabrics | CIBA SPECIALTY CHEMICALS CORP. (US) | 2009-11-10 | — | — | US | disclosed |
| US-7612026-B2 | Sterically hindered amine salts having an N-(alkoxy, cycloalkoxy or aralkoxy)2,2,6,6-tetraalkylsubstituted piperidine moiety; discoloration inhibition, colorfastness | CIBA SPECIALTY CHEMICALS CORP. (US) | 2009-11-03 | — | — | US | disclosed |
| US-7589035-B2 | Stabilized body care products, household products, textiles and fabrics | CIBA SPECIALTY CHEMICALS CORPORATION (US) | 2009-09-15 | — | — | US | disclosed |
| US-20090205144-A1 | Stabilized body care products, household products, textiles and fabrics | LUPIA JOSEPH A | 2009-08-20 | — | — | US | disclosed |
| US-7410936-B2 | Stabilized body care products, household products, textiles and fabrics | CIBA SPECIALTY CHEMICALS CORPORATION (US) | 2008-08-12 | — | — | US | disclosed |
| US-7384464-B2 | Ink jet and recording material | CIBA SPECIALTY CHEMICALS CORPORATION (US) | 2008-06-10 | — | — | US | disclosed |
| EP-1781246-A1 | STABILIZED BODY CARE PRODUCTS, HOUSEHOLD PRODUCTS, TEXTILES AND FABRICS | Ciba SC Holding AG (CH) | 2007-05-09 | — | — | EP | disclosed |
| WO-2006021526-A1 | STABILIZED BODY CARE PRODUCTS, HOUSEHOLD PRODUCTS, TEXTILES AND FABRICS | CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) | 2006-03-02 | — | — | WO | disclosed |
| US-20060040836-A1 | Stabilized body care products, household products, textiles and fabrics | CIBA CORPORATION | 2006-02-23 | — | — | US | disclosed |
| US-20050234151-A1 | Ink jet ink and recording material | CIBA SPECIALTY CHEMICALS CORP. | 2005-10-20 | — | — | US | disclosed |
| WO-2005092992-A1 | INK JET INK AND RECORDING MATERIAL | CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) | 2005-10-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080253981-A1 | Stabilized body care products, household products, textiles and fabrics | DSC1, CUTA, DSG1 | KMT2A 1031/4885MEN1 1581/4885TSHR 1283/4885 |
| US-20060040836-A1 | Stabilized body care products, household products, textiles and fabrics | DSC1, CUTA, DSG1 | KMT2A 1031/4885MEN1 1581/4885TSHR 1283/4885 |
| US-20080221332-A1 | Hindered Amine salt compounds | SLC7A1, H1-0, SLC3A2 | KMT2A 1462/4885MEN1 507/4885TSHR 2669/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.