Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.32 |
| ▸ | RAB9A | P51151 | 3/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL483415 | 0.70 | NPSR1 (0.44) | NPC1RAB9ALMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL3799516 | 0.67 | L3MBTL1 (0.36) | NPC1RAB9ALMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL15611386 | 0.66 | NPSR1 (0.40) | NPC1RAB9ALMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL10393862 | 0.65 | MAPT (0.41) | CA12CA9LMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL28926555 | 0.64 | TSHR (0.39) | CA12CA9SMN1; SMN2ALDH1A1TSHR | |
| SCHEMBL2866274 | 0.63 | NPSR1 (0.41) | NPC1SMN1; SMN2ALDH1A1TSHR | |
| SCHEMBL3799515 | 0.63 | ALDH1A1 (0.31) | SMN1; SMN2ALDH1A1TP53GAAMAPT | |
| SCHEMBL106081 | 0.62 | ALDH1A1 (0.56) | CA12CA9SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL9722907 | 0.62 | MAPT (0.38) | NPC1RAB9ALMNAALDH1A1GAA | |
| SCHEMBL16828923 | 0.61 | POLB (0.35) | NPC1RAB9ACA12CA9SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2139888-A2 | IMIDAZOÝ1,2-A¨PYRIDINE COMPOUNDS AS RECEPTOR TYROSINE KINASE INHIBITORS | Array Biopharma, Inc. (US) | 2010-01-06 | — | — | EP | disclosed |
| WO-2008121687-A2 | IMIDAZO[1,2-A]PYRIDINE COMPOUNDS AS RECEPTOR TYROSINE KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2008-10-09 | — | — | WO | disclosed |