Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | METAP1 | P53582 | 4/20 | 0.37 |
| ▸ | METAP2 | P50579 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | VHL | P40337 | 1/20 | 0.34 |
| ▸ | TDP2 | O95551 | 1/20 | 0.32 |
| ▸ | KDM4A | O75164 | 2/20 | 0.32 |
| ▸ | KDM4B | O94953 | 2/20 | 0.32 |
| ▸ | KDM5C | P41229 | 2/20 | 0.32 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7220708 | 0.72 | LMNA (0.53) | ALDH1A1TSHRMETAP1METAP2KDM4E | |
| SCHEMBL7964249 | 0.71 | TSHR (0.50) | ALDH1A1TSHRMETAP1METAP2KDM4E | |
| SCHEMBL8944146 | 0.70 | METAP2 (0.40) | ALDH1A1TSHRMETAP1METAP2KDM4E | |
| SCHEMBL2832225 | 0.69 | KDM4E (0.54) | METAP1KDM4EPKMKDM4AKDM4B | |
| SCHEMBL9286689 | 0.67 | ALDH1A1 (0.43) | ALDH1A1TSHRMETAP1METAP2KDM4E | |
| SCHEMBL5978656 | 0.67 | ALDH1A1 (0.67) | ALDH1A1TSHRKDM4EPKMCYP1A2 | |
| SCHEMBL2092562 | 0.65 | ALDH1A1 (0.37) | ALDH1A1TSHRKDM4EPKMCYP1A2 | |
| SCHEMBL7045901 | 0.64 | RAB9A (0.45) | TSHRMETAP1METAP2KDM4ECYP1A2 | |
| SCHEMBL3711759 | 0.64 | METAP2 (0.36) | ALDH1A1TSHRMETAP1METAP2KDM4E | |
| SCHEMBL10284703 | 0.64 | KMT2A (0.48) | ALDH1A1TSHRMETAP1METAP2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11988661-B2 | Rapid quantitative test to diagnose polycystic kidney disease | UMC UTRECHT HOLDING, B.V. (NL) | 2024-05-21 | — | — | US | disclosed |
| US-8389736-B2 | Compounds having activity in correcting mutant-CFTR processing and uses thereof | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2013-03-05 | — | — | US | disclosed |
| US-20100273839-A1 | Compounds Having Activity in Correcting Mutant-CFTR Processing and Uses Thereof | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2010-10-28 | — | — | US | disclosed |
| WO-2009051909-A1 | COMPOUNDS HAVING ACTIVITY IN CORRECTING MUTANT-CFTR CELLULAR PROCESSING AND USES THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2009-04-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100273839-A1 | Compounds Having Activity in Correcting Mutant-CFTR Processing and Uses Thereof | CFTR, ABCC5, ABCB11 | ALDH1A1 3083/4885TSHR 3710/4885METAP1 614/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.