Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 1/20 | 0.47 |
| ▸ | METAP1 | P53582 | 1/20 | 0.47 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 8/20 | 0.32 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL277596 | 0.75 | METAP2 (0.51) | METAP2METAP1NPY5RGRIN2BENPP1 | |
| SCHEMBL277595 | 0.75 | METAP2 (0.47) | METAP2METAP1NPY5RGRIN2BENPP1 | |
| SCHEMBL30388675 | 0.75 | NUDT1 (0.50) | METAP2METAP1NPY5RHSD17B10 | |
| SCHEMBL31064848 | 0.75 | SMN1; SMN2 (0.52) | METAP2METAP1NPY5RGRIN2BENPP1 | |
| SCHEMBL375955 | 0.75 | SMN1; SMN2 (0.52) | METAP2METAP1NPY5RGRIN2BENPP1 | |
| SCHEMBL2968462 | 0.75 | METAP2 (0.47) | METAP2METAP1NPY5RENPP1 | |
| SCHEMBL5632 | 0.75 | NUDT1 (0.50) | METAP2METAP1NPY5RHSD17B10 | |
| SCHEMBL3894 | 0.75 | METAP2 (0.47) | METAP2METAP1NPY5RENPP1 | |
| SCHEMBL3014791 | 0.75 | HSD17B10 (0.57) | METAP2METAP1NPY5RHTTHSD17B10 | |
| Hydrochloric Acid SCHEMBL357697 | 0.73 | NUDT1 (0.48) | METAP2METAP1NPY5RHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6262254-B1 | 8-FLUORO-9-((2-HYDROXYETHOXY)METHYL))GUANINE / (8-FLUOROACYCLOVIR) USEFUL AS ANTICANCER AND ANTIVIRAL AGENT | THE REGENTS OF UNIV. OF CALIFORNIA | 2001-07-17 | — | — | US | claimed |
| US-5861503-A | FLUORINATING WITH FLUORINE OR ACETYL HYPOFLUORITE | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1999-01-19 | — | — | US | claimed |
| EP-4612294-A2 | MODIFIED SHORT INTERFERING NUCLEIC ACID (SINA) MOLECULES AND USES THEREOF | Aligos Therapeutics, Inc. (US) | 2025-09-10 | — | — | EP | disclosed |
| WO-2023138524-A1 | KRAS G12D DEGRADATION AGENT AND MEDICAL USE THEREOF | 贝达药业股份有限公司 | 2023-07-27 | — | — | WO | disclosed |
| EP-4133080-A1 | SHORT INTERFERING NUCLEIC ACID (SINA) MOLECULES AND USES THEREOF FOR CORONAVIRUS DISEASES | Aligos Therapeutics, Inc. (US) | 2023-02-15 | — | — | EP | disclosed |
| US-20210008226-A1 | SYSTEMIC DELIVERY OF MYOSTATIN SHORT INTERFERING NUCLEIC ACIDS (SINA) CONJUGATED TO A LIPOPHILIC MOIETY | BANK OF AMERICA, N.A. | 2021-01-14 | — | — | US | disclosed |
| CN-103819524-A | 3'-fluorine substituted purine nucleoside analog, preparation method and application thereof | ZHENGZHOU GRANLEN PHARMATECH LTD | 2014-05-28 | — | — | CN | disclosed |
| CN-101240001-B | 2' -fluoro nucleosides | UNIV EMORY | 2013-10-16 | — | — | CN | disclosed |
| CN-101646657-B | Process for producing trichloropyrimidine compound | SUMITOMO CHEMICAL CO JP | 2012-08-08 | — | — | CN | disclosed |
| CN-101089010-B | 2' -fluoronucleosides | EMORY UNIVERSITY (US) | 2011-12-14 | — | — | CN | disclosed |
| WO-2010091878-A2 | MEANS FOR INHIBITING THE EXPRESSION OF OPA1 | SILENCE THERAPEUTICS AG (DE) | 2010-08-19 | — | — | WO | disclosed |
| WO-2003070969-A2 | RNA INTERFERENCE MEDIATED INHIBITION OF BCL2 GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) | SIRNA THERAPEUTICS, INC. (US) | 2003-08-28 | — | — | WO | disclosed |
| CN-1100777-C | N-heterocyclic derivatives as NOS inhibitor | BERLEX LAB (US) | 2003-02-05 | — | — | CN | disclosed |
| US-6262254-B1 | 8-FLUORO-9-((2-HYDROXYETHOXY)METHYL))GUANINE / (8-FLUOROACYCLOVIR) USEFUL AS ANTICANCER AND ANTIVIRAL AGENT | THE REGENTS OF UNIV. OF CALIFORNIA | 2001-07-17 | — | — | US | disclosed |
| US-6262254-B1 | 8-FLUORO-9-((2-HYDROXYETHOXY)METHYL))GUANINE / (8-FLUOROACYCLOVIR) USEFUL AS ANTICANCER AND ANTIVIRAL AGENT | THE REGENTS OF UNIV. OF CALIFORNIA | 2001-07-17 | — | — | US | disclosed |
| US-6262254-B1 | 8-FLUORO-9-((2-HYDROXYETHOXY)METHYL))GUANINE / (8-FLUOROACYCLOVIR) USEFUL AS ANTICANCER AND ANTIVIRAL AGENT | THE REGENTS OF UNIV. OF CALIFORNIA | 2001-07-17 | — | — | US | disclosed |
| CN-1252799-A | N-heterocyclic derivatives as NOS inhibitor | BERLEX LAB (US) | 2000-05-10 | — | — | CN | disclosed |
| US-5861503-A | FLUORINATING WITH FLUORINE OR ACETYL HYPOFLUORITE | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1999-01-19 | — | — | US | disclosed |
| US-5861503-A | FLUORINATING WITH FLUORINE OR ACETYL HYPOFLUORITE | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1999-01-19 | — | — | US | disclosed |
| US-5861503-A | FLUORINATING WITH FLUORINE OR ACETYL HYPOFLUORITE | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1999-01-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210008226-A1 | SYSTEMIC DELIVERY OF MYOSTATIN SHORT INTERFERING NUCLEIC ACIDS (SINA) CONJUGATED TO A LIPOPHILIC MOIETY | TNNC1, MYOF, MSTN | METAP2 1182/4885METAP1 919/4885NPY5R 4619/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.