SCHEMBL380360

SCHEMBL380360

C=CC(=Cc1ccc(N(c2ccccc2)c2ccccc2)cc1)C(=O)O

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TP53 P04637 1/20 0.40
AKR1C3 P42330 1/20 0.38
KMT2A Q03164 3/20 0.38
TRPM8 Q7Z2W7 2/20 0.38
MEN1 O00255 2/20 0.38
PSMD14 O00487 1/20 0.38
APAF1 O14727 1/20 0.38
USP2 O75604 1/20 0.38
POLB P06746 1/20 0.38
MMP2 P08253 1/20 0.38
RAD52 P43351 1/20 0.38
CASP6 P55212 1/20 0.38
UBE2N P61088 1/20 0.38
HDAC3 O15379 1/20 0.37
HDAC1 Q13547 1/20 0.37
HDAC2 Q92769 1/20 0.37
HDAC8 Q9BY41 1/20 0.37
HDAC6 Q9UBN7 1/20 0.37
ALDH1A1 P00352 3/20 0.37
MAPT P10636 3/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5332797 0.84 AKR1C3 (0.52) TP53AKR1C3KMT2AMEN1POLB
SCHEMBL175544 0.84 AKR1C3 (0.52) TP53AKR1C3KMT2AMEN1POLB
SCHEMBL13893223 0.81 ALDH1A1 (0.40) KMT2ATRPM8MEN1POLBHDAC3
Acetic Acid SCHEMBL6697876 0.79 AKR1C3 (0.57) TP53AKR1C3KMT2AMEN1POLB
SCHEMBL11673166 0.79 TP53 (0.58) TP53AKR1C3KMT2ATRPM8MEN1
SCHEMBL11673168 0.79 TP53 (0.58) TP53AKR1C3KMT2ATRPM8MEN1
SCHEMBL11673262 0.76 AKR1C3 (0.69) TP53AKR1C3KMT2ATRPM8ALDH1A1
Acrylic Acid SCHEMBL14672542 0.76 AKT1 (0.48) TP53KMT2ATRPM8MEN1POLB
SCHEMBL7797919 0.75 ALDH1A1 (0.47) AKR1C3KMT2AMEN1POLBALDH1A1
SCHEMBL11673895 0.73 TBXAS1 (0.51) AKR1C3KMT2AMEN1ALDH1A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2261299-B1 AROMATIC AMINE COMPOSITIONS AND ELECTRONIC DEVICES MADE WITH SUCH COMPOSITIONS DU PONT (US) 2016-01-06 EP disclosed
US-8716697-B2 Electronic devices made with crosslinkable compounds and copolymers E I DU PONT DE NEMOURS AND COMPANY (US) 2014-05-06 US disclosed
EP-1723214-B1 AROMATIC AMINE COMPOSITIONS COMPRISING AND ELECTRONIC DEVICES MADE WITH SUCH COMPOSITIONS DU PONT (US) 2012-01-25 EP disclosed
EP-2261299-A2 Aromatic amine compositions and electronic devices made with such compositions E. I. du Pont de Nemours and Company (US) 2010-12-15 EP disclosed
US-20080132622-A1 ELECTRONIC DEVICES MADE WITH CROSSLINKABLE COMPOUNDS AND COPOLYMERS E. I. DU PONT DE NEMOURS AND COMPANY 2008-06-05 US disclosed
US-7365230-B2 Cross-linkable polymers and electronic devices made with such polymers E.I. DU PONT DE NEMOURS AND COMPANY (US) 2008-04-29 US disclosed
EP-1723214-A1 AROMATIC AMINE COMPOSITIONS COMPRISING AND ELECTRONIC DEVICES MADE WITH SUCH COMPOSITIONS E.I.Du pont de nemours and company (US) 2006-11-22 EP disclosed
WO-2005083034-A1 AROMATIC AMINE COMPOSITIONS COMPRISING AND ELECTRONIC DEVICES MADE WITH SUCH COMPOSITIONS E.I. DUPONT DE NEMOURS AND COMPANY (US) 2005-09-09 WO disclosed
US-20050184287-A1 Cross-linkable polymers and electronic devices made with such polymers LG CHEM, LTD. (KR) 2005-08-25 US disclosed
US-4018606-A Organic azo pigment sensitizers for photoconductive layers EASTMAN KODAK COMPANY (US) 1977-04-19 US disclosed
US-4018607-A Crystalline organic pigment sensitizers for photoconductive layers EASTMAN KODAK COMPANY (US) 1977-04-19 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080132622-A1 ELECTRONIC DEVICES MADE WITH CROSSLINKABLE COMPOUNDS AND COPOLYMERS GJB2, ERCC1, GJA1 TP53 3961/4885AKR1C3 4396/4885KMT2A 2809/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.