Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 4/20 | 0.32 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3815943 | 0.86 | CNR2 (0.37) | TSHRKDM4EALDH1A1HSD11B1P2RX4 | |
| SCHEMBL3815358 | 0.85 | LMNA (0.34) | TSHRALDH1A1CNR2LMNA | |
| SCHEMBL3814191 | 0.82 | HSD11B1 (0.35) | TSHRKDM4EALDH1A1CA12CA2 | |
| SCHEMBL3815611 | 0.81 | RXFP1 (0.40) | TSHRKDM4EALDH1A1 | |
| SCHEMBL3815221 | 0.80 | NR1H4 (0.36) | ALDH1A1HSD11B1CNR2 | |
| SCHEMBL3816741 | 0.75 | SRD5A2 (0.36) | TSHRKDM4EALDH1A1HSD11B1P2RX4 | |
| SCHEMBL3820671 | 0.75 | ALDH1A1 (0.34) | ALDH1A1P2RX4LMNA | |
| SCHEMBL3818150 | 0.73 | NR1H4 (0.39) | ALDH1A1CA12CA2CA9HSD11B1 | |
| SCHEMBL31153514 | 0.68 | RXFP1 (0.51) | TSHRKDM4EALDH1A1 | |
| SCHEMBL3816090 | 0.65 | L3MBTL1 (0.40) | KDM4ECA12CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2090576-A1 | 6-halo-pyrazolo[1,5-a]pyridines, a process for their preparation and their use as metabotropic glutamate receptor (mGluR) modulators | Merz Pharma GmbH & Co.KGaA (DE) | 2009-08-19 | — | — | EP | claimed |
| EP-2090576-A1 | 6-halo-pyrazolo[1,5-a]pyridines, a process for their preparation and their use as metabotropic glutamate receptor (mGluR) modulators | Merz Pharma GmbH & Co.KGaA (DE) | 2009-08-19 | — | — | EP | disclosed |
| WO-2009095253-A1 | 6-HALO-PYRAZOLO[1, 5-A]PYRIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR (MGLUR) MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2009-08-06 | — | — | WO | disclosed |