Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A2 | P31213 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 5/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | P2RX5 | Q93086 | 1/20 | 0.34 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | PKM | P14618 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | HSD11B2 | P80365 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.32 |
| ▸ | MARS1 | P56192 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3815943 | 0.88 | CNR2 (0.37) | SRD5A2HSD11B1MEN1KMT2AP2RX5 | |
| SCHEMBL3815221 | 0.86 | NR1H4 (0.36) | HSD11B1P2RX7ALDH1A1CNR2NR1H4 | |
| SCHEMBL3810745 | 0.83 | MARS1 (0.38) | KDM4EL3MBTL1MARS1 | |
| SCHEMBL3820671 | 0.81 | ALDH1A1 (0.34) | MEN1KMT2AP2RX4P2RX7P2RX2 | |
| SCHEMBL3818150 | 0.78 | NR1H4 (0.39) | HSD11B1P2RX7NPSR1ALDH1A1L3MBTL1 | |
| SCHEMBL3813472 | 0.75 | TSHR (0.33) | HSD11B1P2RX4LMNAKDM4EALDH1A1 | |
| SCHEMBL3815358 | 0.71 | LMNA (0.34) | HTTLMNANPSR1ALDH1A1CNR2 | |
| SCHEMBL28521561 | 0.70 | RPA1 (0.40) | KMT2ALMNAKDM4EALDH1A1L3MBTL1 | |
| SCHEMBL3814191 | 0.69 | HSD11B1 (0.35) | HSD11B1P2RX4P2RX7LMNAKDM4E | |
| SCHEMBL13720894 | 0.69 | MEN1 (0.39) | MEN1KMT2APKMALDH1A1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2090576-A1 | 6-halo-pyrazolo[1,5-a]pyridines, a process for their preparation and their use as metabotropic glutamate receptor (mGluR) modulators | Merz Pharma GmbH & Co.KGaA (DE) | 2009-08-19 | — | — | EP | claimed |
| EP-2090576-A1 | 6-halo-pyrazolo[1,5-a]pyridines, a process for their preparation and their use as metabotropic glutamate receptor (mGluR) modulators | Merz Pharma GmbH & Co.KGaA (DE) | 2009-08-19 | — | — | EP | disclosed |
| WO-2009095253-A1 | 6-HALO-PYRAZOLO[1, 5-A]PYRIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR (MGLUR) MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2009-08-06 | — | — | WO | disclosed |