Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 4/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 11/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 2/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | RPA1 | P27694 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3816741 | 0.86 | SRD5A2 (0.36) | NR1H4HSD11B1P2RX7CNR2ALDH1A1 | |
| SCHEMBL3820671 | 0.85 | ALDH1A1 (0.34) | NR1H4P2RX7ALDH1A1POLB | |
| SCHEMBL3818150 | 0.82 | NR1H4 (0.39) | NR1H4HSD11B1P2RX7CNR1CNR2 | |
| SCHEMBL3817231 | 0.81 | RPA1 (0.41) | RPA1 | |
| SCHEMBL3813472 | 0.80 | TSHR (0.33) | HSD11B1CNR2ALDH1A1 | |
| SCHEMBL3815943 | 0.75 | CNR2 (0.37) | HSD11B1P2RX7CNR2ALDH1A1 | |
| SCHEMBL3815358 | 0.75 | LMNA (0.34) | CNR2ALDH1A1POLB | |
| SCHEMBL3814191 | 0.73 | HSD11B1 (0.35) | HSD11B1P2RX7CNR1CNR2ALDH1A1 | |
| SCHEMBL4181367 | 0.66 | PTGER1 (0.41) | RPA1 | |
| SCHEMBL3810745 | 0.65 | MARS1 (0.38) | RPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2090576-A1 | 6-halo-pyrazolo[1,5-a]pyridines, a process for their preparation and their use as metabotropic glutamate receptor (mGluR) modulators | Merz Pharma GmbH & Co.KGaA (DE) | 2009-08-19 | — | — | EP | claimed |
| EP-2090576-A1 | 6-halo-pyrazolo[1,5-a]pyridines, a process for their preparation and their use as metabotropic glutamate receptor (mGluR) modulators | Merz Pharma GmbH & Co.KGaA (DE) | 2009-08-19 | — | — | EP | disclosed |
| WO-2009095253-A1 | 6-HALO-PYRAZOLO[1, 5-A]PYRIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR (MGLUR) MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2009-08-06 | — | — | WO | disclosed |