Known targets — ChEMBL curated mechanism
ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO
The experimentally established mechanism targets of Diethyl Pyrocarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOAT1 | P35610 | 1/20 | 0.94 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.71 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | MGAM | O43451 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | SI | P14410 | 1/20 | 0.48 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.48 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Diethyl Pyrocarbonate SCHEMBL15582 | 0.97 | SOAT1 (1.00) | SOAT1ALDH1A1LMNAHSD17B10ALOX15 | |
| Diethyl Pyrocarbonate SCHEMBL30366210 | 0.97 | SOAT1 (1.00) | SOAT1ALDH1A1LMNAHSD17B10ALOX15 | |
| Diethyl Pyrocarbonate SCHEMBL28670714 | 0.94 | SOAT1 (0.94) | SOAT1ALDH1A1LMNAHSD17B10ALOX15 | |
| SCHEMBL28247811 | 0.94 | SOAT1 (0.94) | SOAT1ALDH1A1LMNAHSD17B10ALOX15 | |
| Diethyl Pyrocarbonate SCHEMBL28040134 | 0.91 | SOAT1 (0.88) | SOAT1ALDH1A1LMNAHSD17B10ALOX15 | |
| Water SCHEMBL22362219 | 0.87 | — | — | |
| Diethyl Pyrocarbonate SCHEMBL28265090 | 0.86 | SOAT1 (0.79) | SOAT1ALDH1A1LMNAHSD17B10ALOX15 | |
| Diethyl Pyrocarbonate SCHEMBL8342707 | 0.86 | SOAT1 (0.79) | SOAT1ALDH1A1LMNAHSD17B10ALOX15 | |
| SCHEMBL641445 | 0.86 | SOAT1 (0.79) | SOAT1ALDH1A1LMNAHSD17B10ALOX15 | |
| Diethyl Pyrocarbonate SCHEMBL28111799 | 0.86 | SOAT1 (0.79) | SOAT1ALDH1A1LMNAHSD17B10ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 53 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114159576-B | Preparation method of tumor pH response charge reversal loaded miRNA nano-composite | 武汉理工大学 | 2023-03-31 | — | — | CN | claimed |
| CN-115181652-A | Detection device and detection method | 香港城市大学 | 2022-10-14 | — | — | CN | claimed |
| CN-110755382-B | Targeted nucleic acid medicament and preparation method and application thereof | 中国医学科学院医药生物技术研究所 | 2022-07-12 | — | — | CN | claimed |
| CN-114159576-A | Preparation method of tumor pH response charge reversal loaded miRNA nano-composite | 武汉理工大学 | 2022-03-11 | — | — | CN | claimed |
| CN-119753133-A | Methylation biomarker for repeated pregnancy loss and application thereof | 济南市妇幼保健院 | 2025-04-04 | — | — | CN | disclosed |
| CN-119405589-A | Double-response hydrogel and preparation method and application thereof | 中国人民解放军空军军医大学 | 2025-02-11 | — | — | CN | disclosed |
| CN-119144707-A | Primer composition and kit for detecting activity of telomerase of humanized cells | 天津昂赛细胞基因工程有限公司 | 2024-12-17 | — | — | CN | disclosed |
| US-20240398829-A1 | A COBALT-CONTAINING ACIDIC AMINO ACID COMPLEX AND ITS USE FOR TREATING CANCER | AMELIO BIOTECH CO., LTD. (TW) | 2024-12-05 | — | — | US | disclosed |
| EP-3929303-B1 | COMPOSITIONS, METHODS AND KITS FOR DIAGNOSIS OF A GASTROENTEROPANCREATIC NEUROENDOCRINE NEOPLASM | Clifton Life Sciences LLC (KN) | 2024-12-04 | — | — | EP | disclosed |
| CN-119015502-A | Hydrogel stent for embedding M2 type macrophages and preparation method and application thereof | 杭州师范大学 | 2024-11-26 | — | — | CN | disclosed |
| CN-118995933-A | Marker for gastric cancer peritoneal metastasis, detection product and application thereof | 苏州大学附属第一医院 | 2024-11-22 | — | — | CN | disclosed |
| CN-118879850-A | Application of PINK1 protein as biomarker of nicotine-related non-alcoholic fatty liver disease | 温州医科大学附属第一医院 | 2024-11-01 | — | — | CN | disclosed |
| CN-111763663-B | Gastrodia elata glucosyltransferase gene and application thereof | 昆明理工大学 | 2022-04-15 | — | — | CN | disclosed |
| WO-2022065724-A1 | CD47 BINDER AND LIPOSOME COMPLEX FOR TREATING CANCER | 비피진 주식회사 | 2022-03-31 | — | — | WO | disclosed |
| WO-2022065726-A1 | LIPOSOME COMPLEX FOR CANCER TREATMENT, COMPRISING NOVEL CD47 BINDER AND POLYNUCLEOTIDE | 비피진 주식회사 | 2022-03-31 | — | — | WO | disclosed |
| WO-2022065725-A1 | POLYNUCLEOTIDE FOR CANCER TREATMENT, ENCODING 5'-NUCLEOTIDASE MODIFIED PROTEIN | 비피진 주식회사 | 2022-03-31 | — | — | WO | disclosed |
| CN-109295168-B | Manganese dioxide nanosheet-mediated ratio fluorescence biosensor for detecting and imaging intracellular microRNA | 山东大学 | 2022-02-15 | — | — | CN | disclosed |
| CN-104805075-A | Extraction method of RNA (Ribonucleic Acid) of grape branch | UNIV GANSU AGRICULTURAL | 2015-07-29 | — | — | CN | disclosed |
| WO-2009056651-A1 | ANGIOTENSIN-CARRIER FORMULATION | CYTOS BIOTECHNOLOGY AG (CH) | 2009-05-07 | — | — | WO | disclosed |
| WO-1992013077-A1 | A cDNA ENCODING THE TYPE I IODOTHYRONINE 5' DEIODINASE | BRIGHAM AND WOMEN'S HOSPITAL (US) | 1992-08-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240398829-A1 | A COBALT-CONTAINING ACIDIC AMINO ACID COMPLEX AND ITS USE FOR TREATING CANCER | BCAT1, BCAT2, CA12 | SOAT1 4595/4885ALDH1A1 1513/4885LMNA 4506/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.