Parthenin

Parthenin

SCHEMBL382003

C=C1C(=O)O[C@@H]2[C@H]1CC[C@H](C)[C@]1(O)C=CC(=O)[C@@]21C

nearest known ligand 0.58

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PAX8 Q06710 1/20 0.58
▸ PTGS2 P35354 3/20 0.50
▸ MAPT P10636 6/20 0.38
▸ PKM P14618 5/20 0.38
▸ RAB9A P51151 4/20 0.38
▸ RECQL P46063 2/20 0.38
▸ NPC1 O15118 3/20 0.36
▸ HTT P42858 3/20 0.36
▸ XBP1 P17861 2/20 0.36
▸ MDM2 Q00987 2/20 0.36
▸ ALDH1A1 P00352 5/20 0.34
▸ POLB P06746 2/20 0.34
▸ MAPK1 P28482 2/20 0.34
▸ NLRP3 Q96P20 2/20 0.34
▸ TERT O14746 1/20 0.34
▸ GLA P06280 1/20 0.34
▸ AGTR1 P30556 1/20 0.34
▸ SMN1; SMN2 Q16637 1/20 0.34
▸ TDP1 Q9NUW8 1/20 0.34
▸ GPR55 Q9Y2T6 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hymenin SCHEMBL29711376 1.00 PAX8 (0.58) PAX8PTGS2MAPTPKMRAB9A
Hymenin SCHEMBL12355327 1.00 PAX8 (0.58) PAX8PTGS2MAPTPKMRAB9A
Hymenin SCHEMBL11892893 1.00 PAX8 (0.58) PAX8PTGS2MAPTPKMRAB9A
SCHEMBL4058769 0.77 PAX8 (0.55) PAX8PTGS2MAPTPKMRAB9A
SCHEMBL4060824 0.74 PAX8 (0.51) PAX8PTGS2PKMNLRP3
Coronopilin SCHEMBL8422737 0.73 PAX8 (1.00) PAX8PTGS2MAPTPKMRAB9A
SCHEMBL4060819 0.73 PAX8 (0.50) PAX8PTGS2PKMNLRP3
SCHEMBL4067330 0.72 PAX8 (0.61) PAX8PTGS2MAPTPKMRAB9A
SCHEMBL4379311 0.72 PAX8 (0.48) PAX8PTGS2NLRP3
SCHEMBL4067886 0.71 PAX8 (0.59) PAX8PTGS2MAPTPKMRAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 118 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250351832-A1 PHYTOCHEMICALS AS BIOPESTICIDES AND BIOSTIMULANTS KAY BEE BIO ORGANICS PVT LTD (IN) 2025-11-20 — — US claimed
EP-3349584-B1 MEDICINAL AMBROSIA PLANT EXTRACTS EL SAWY MOHAMED FAKHR EL DIN (EG) 2025-07-16 — — EP claimed
US-20250089726-A1 BOTANICAL BASED BIO-STIMULANT, BIO-ACARICIDAL COMPOSITIONS KAY BEE BIO ORGANICS PVT LTD (IN) 2025-03-20 — — US claimed
US-11911428-B2 Medicinal ambrosia maritima extracts HELMY SHERINE HASSAN ABBAS (EG) 2024-02-27 — — US claimed
WO-2023159062-A2 ANABOLIC DRUGS STIMULATING TYPE II COLLAGEN PRODUCTION FROM CHONDROCYTES OR THEIR PROGENITORS UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. (US) 2023-08-24 — — WO claimed
US-20220362321-A1 MEDICINAL AMBROSIA MARITIMA EXTRACTS HELMY SHERINE HASSAN ABBAS (EG) 2022-11-17 — — US claimed
US-10653739-B2 Medicinal ambrosia maritima extracts EL SAWY MOHAMED FAKHR EL DIN (EG) 2020-05-19 — — US claimed
EP-3349584-A1 MEDICINAL AMBROSIA PLANT EXTRACTS El-Sawy, Mohamed Fakhr El-Din (EG) 2018-07-25 — — EP claimed
WO-2017044860-A1 MEDICINAL AMBROSIA PLANT EXTRACTS EL-SAWY MOHAMED FAKHR EL-DIN (EG) 2017-03-16 — — WO claimed
US-20170071994-A1 MEDICINAL AMBROSIA MARITIMA EXTRACTS EL-SAWY MOHAMED FAKHR EL-DIN (EG) 2017-03-16 — — US claimed
EP-2265620-B1 SPIRO DERIVATIVES OF PARTHENIN AS NOVEL ANTICANCER AGENTS COUNCIL SCIENT IND RES (IN) 2014-06-18 — — EP claimed
US-20110201661-A1 Spiro Derivatives of Parthenin as Novel Anticancer Agents COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) 2011-08-18 — — US claimed
EP-2265620-A1 SPIRO DERIVATIVES OF PARTHENIN AS NOVEL ANTICANCER AGENTS Council Of Scientific & Industrial Research (IN) 2010-12-29 — — EP claimed
WO-2009122447-A1 SEMI-SYNTHETIC SESQUITERPENE LACTONE PARTHENIN COMPOUND USEFUL FOR CYTOTOXICITY AGAINST CANCER CELL LINES AND ANTICANDER AGENT COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) 2009-10-08 — — WO claimed
WO-2009110007-A1 SPIRO DERIVATIVES OF PARTHENIN AS NOVEL ANTICANCER AGENTS COUNCIL QF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) 2009-09-11 — — WO claimed
WO-2026099819-A1 BACTERICIDAL, FUNGICIDAL, AND NEMATICIDAL FORMULATIONS OF PHENOXYETHANOL FOR AGRICULTURAL USE IN PLANTS Química Agronómica de México S. de R.L. de C.V. (MX) 2026-05-15 — — WO disclosed
US-20260130367-A1 BACTERICIDAL, FUNGICIDAL, AND NEMATICIDAL FORMULATIONS OF PHENOXYETHANOL FOR AGRICULTURAL USE IN PLANTS Química Agronómica de México S. de R.L. de C.V. (MX) 2026-05-14 — — US disclosed
WO-2000055338-A9 SESQUITERPENOID SYNTHASE GENES AND THEIR USE FOR INFLUENCING BITTERNESS AND RESISTANCE IN PLANTS RES INST FOR AGROBIOLOGY AND S (NL) 2001-03-15 — — WO disclosed
WO-2000055338-A1 SESQUITERPENOID SYNTHASE GENES AND THEIR USE FOR INFLUENCING BITTERNESS AND RESISTANCE IN PLANTS RESEARCH INSTITUTE FOR AGROBIOLOGY AND SOIL FERTILITY (AB-DLO) (NL) 2000-09-21 — — WO disclosed
US-5905089-A USEFUL IN SUPPRESSING EARLY PROINFLAMMATORY CYTOKINES AND IN AMELIORATING SEPTIC SHOCK AND OTHER SEVERE INFLAMMATORY DISORDERS BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE (US) 1999-05-18 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250351832-A1 PHYTOCHEMICALS AS BIOPESTICIDES AND BIOSTIMULANTS ACHE, DDT, BCHE PAX8 3845/4885PTGS2 3567/4885MAPT 996/4885
US-20110201661-A1 Spiro Derivatives of Parthenin as Novel Anticancer Agents CDK10, NEK10, AKR1B10 PAX8 4479/4885PTGS2 2342/4885MAPT 4489/4885
US-20260130367-A1 BACTERICIDAL, FUNGICIDAL, AND NEMATICIDAL FORMULATIONS OF PHENOXYETHANOL FOR AGRICULTURAL USE IN PLANTS NAPEPLD, CLPP, HPD PAX8 938/4885PTGS2 3253/4885MAPT 398/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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