Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.39 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 5/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | XDH | P47989 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | NAAA | Q02083 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7204740 | 0.89 | TSHR (0.38) | LMNAALDH1A1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL7205105 | 0.86 | RECQL (0.37) | LMNAALDH1A1KDM4EMAPT | |
| SCHEMBL7207482 | 0.85 | LMNA (0.35) | LMNAALDH1A1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL2440388 | 0.84 | LMNA (0.52) | LMNAALDH1A1CSNK2A2CSNK2A1RAB9A | |
| SCHEMBL7206799 | 0.84 | LMNA (0.33) | LMNAALDH1A1SMN1; SMN2MAPTL3MBTL1 | |
| SCHEMBL7063863 | 0.83 | LMNA (0.51) | LMNAALDH1A1CSNK2A2CSNK2A1XDH | |
| SCHEMBL7063685 | 0.83 | LMNA (0.51) | LMNAALDH1A1CSNK2A2CSNK2A1XDH | |
| SCHEMBL7064550 | 0.80 | LMNA (0.47) | LMNAALDH1A1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL7212657 | 0.80 | NAAA (0.43) | LMNARAB9ANPC1SMN1; SMN2NAAA | |
| SCHEMBL7205833 | 0.78 | ALDH1A1 (0.42) | LMNAALDH1A1SMN1; SMN2HPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0882734-B1 | 5'-Deoxy-cytidine derivatives | HOFFMANN LA ROCHE (CH) | 2009-08-26 | — | — | EP | disclosed |
| US-6211166-B1 | COADMINISTERED WITH A 5-FLUOROURACIL DERIVATIVE; ANTICARCINOGENIC AGENTS | HOFFMAN-LA ROCHE INC. | 2001-04-03 | — | — | US | disclosed |
| EP-0882734-A2 | 5'-Deoxy-cytidine derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1998-12-09 | — | — | EP | disclosed |