Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAAA | Q02083 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.38 |
| ▸ | BCHE | P06276 | 2/20 | 0.37 |
| ▸ | ACHE | P22303 | 2/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MGLL | Q99685 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7204740 | 0.84 | TSHR (0.38) | SMN1; SMN2NPC1RAB9AMEN1KMT2A | |
| SCHEMBL7205833 | 0.81 | ALDH1A1 (0.42) | SMN1; SMN2RECQLMEN1KMT2AGAA | |
| SCHEMBL3825844 | 0.80 | LMNA (0.41) | NAAASMN1; SMN2NPC1RAB9ALMNA | |
| SCHEMBL7204714 | 0.78 | MEN1 (0.47) | MEN1KMT2ACHRNA7POLBLMNA | |
| SCHEMBL7207482 | 0.77 | LMNA (0.35) | SMN1; SMN2RAB9AMEN1KMT2ABCHE | |
| SCHEMBL7205105 | 0.76 | RECQL (0.37) | RECQLMEN1KMT2ABCHEACHE | |
| SCHEMBL7205752 | 0.74 | BCHE (0.41) | SMN1; SMN2NPC1RAB9ABCHEACHE | |
| SCHEMBL8193744 | 0.72 | LMNA (0.56) | NAAALMNA | |
| SCHEMBL7210398 | 0.72 | LMNA (0.56) | NAAALMNA | |
| SCHEMBL14609868 | 0.71 | ROCK2 (0.46) | NAAASMN1; SMN2NPC1RECQLRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1060183-B1 | 5'-DEOXYCYTIDINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-04-23 | — | — | EP | disclosed |
| EP-1060183-A1 | 5'-DEOXYCYTIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-12-20 | — | — | EP | disclosed |
| WO-1999040099-A1 | 5'-DEOXYCYTIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1999-08-12 | — | — | WO | disclosed |