Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGIR | P43119 | 1/20 | 0.53 |
| ▸ | ITGB3 | P05106 | 3/20 | 0.49 |
| ▸ | ITGAV | P06756 | 3/20 | 0.49 |
| ▸ | ITGA2B | P08514 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.42 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.42 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.41 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.41 |
| ▸ | NOS2 | P35228 | 1/20 | 0.40 |
| ▸ | METAP1 | P53582 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL382698 | 0.93 | ITGB3 (0.53) | PTGIRITGB3ITGAVITGA2BALDH1A1 | |
| SCHEMBL382510 | 0.81 | NOS2 (0.51) | ALDH1A1MEN1KMT2AHSP90AA1MAPT | |
| SCHEMBL378108 | 0.76 | MEN1 (0.50) | ALDH1A1MEN1KMT2AHSP90AA1MAPT | |
| Hydrochloric Acid SCHEMBL2514818 | 0.76 | MEN1 (0.50) | ALDH1A1MEN1KMT2AHSP90AA1TSHR | |
| SCHEMBL384016 | 0.76 | ITGB3 (0.56) | ITGB3ITGAVITGA2BADRA2AADRA2B | |
| SCHEMBL384017 | 0.76 | ITGB3 (0.56) | ITGB3ITGAVITGA2BADRA2AADRA2B | |
| SCHEMBL8207095 | 0.75 | HTT (0.52) | ALDH1A1MEN1KMT2AHSP90AA1MAPT | |
| SCHEMBL383015 | 0.74 | OPRK1 (0.51) | ALDH1A1MEN1KMT2AHSP90AA1MAPT | |
| SCHEMBL382149 | 0.74 | OPRK1 (0.51) | ALDH1A1MEN1KMT2AHSP90AA1MAPT | |
| SCHEMBL378276 | 0.74 | TDP1 (0.60) | ALDH1A1MEN1KMT2AHSP90AA1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1074543-B1 | AMINOPIPERIDINE DERIVATIVES AS INTEGRIN ALPHA V BETA 3 ANTAGONISTS | MEIJI SEIKA PHARMA CO LTD (JP) | 2012-01-25 | — | — | EP | disclosed |
| US-6420558-B1 | COMPOUNDS WITH AMIDINE GROUPS ANTAGONISTIC ACTIVITY, CELL ADHESION INHIBITORY ACTIVITY, HUMAN PLATELET AGGREGATION INHIBITORY ACTIVITY, AND THERAPEUTIC AGENTS | MEIJI SEIKA KAISHA, LTD. (JP) | 2002-07-16 | — | — | US | disclosed |
| EP-1074543-A1 | AMINOPIPERIDINE DERIVATIVES AS INTEGRIN ALPHA V BETA 3 ANTAGONISTS | MEIJI SEIKA KAISHA LTD. (JP) | 2001-02-07 | — | — | EP | disclosed |