Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 8/20 | 0.53 |
| ▸ | DRD3 | P35462 | 8/20 | 0.53 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.49 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | METAP1 | P53582 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31736836 | 0.85 | TRIM24 (0.45) | DRD2DRD3TRIM24TRIM33ALDH1A1 | |
| SCHEMBL383016 | 0.80 | DRD2 (0.55) | DRD2DRD3KDM4EMAPK1GAA | |
| SCHEMBL383328 | 0.78 | DRD2 (0.51) | DRD2DRD3ALDH1A1KDM4EMAPK1 | |
| SCHEMBL383329 | 0.78 | DRD2 (0.51) | DRD2DRD3MAPK1 | |
| SCHEMBL382518 | 0.78 | DRD2 (0.53) | DRD2DRD3KDM4EMAPK1GAA | |
| SCHEMBL7660354 | 0.74 | MAPT (0.62) | TRIM24TRIM33ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL382510 | 0.73 | NOS2 (0.51) | DRD2DRD3ALDH1A1KDM4EMAPK1 | |
| SCHEMBL31737288 | 0.73 | ALDH1A1 (0.41) | TRIM24TRIM33ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL383181 | 0.72 | CASR (0.54) | DRD2DRD3METAP1 | |
| SCHEMBL382583 | 0.72 | CASR (0.54) | DRD2DRD3METAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1074543-B1 | AMINOPIPERIDINE DERIVATIVES AS INTEGRIN ALPHA V BETA 3 ANTAGONISTS | MEIJI SEIKA PHARMA CO LTD (JP) | 2012-01-25 | — | — | EP | disclosed |
| CN-1140511-C | As integrin alphavβ3Aminopiperidine derivatives as antagonists | �����Ƹ���ʽ���� | 2004-03-03 | — | — | CN | disclosed |
| US-6420558-B1 | COMPOUNDS WITH AMIDINE GROUPS ANTAGONISTIC ACTIVITY, CELL ADHESION INHIBITORY ACTIVITY, HUMAN PLATELET AGGREGATION INHIBITORY ACTIVITY, AND THERAPEUTIC AGENTS | MEIJI SEIKA KAISHA, LTD. (JP) | 2002-07-16 | — | — | US | disclosed |
| CN-1303377-A | Amino piperidine derivatives as integrin alpha beta 3 antagonists | MEIJI SEIKA KAISHA (JP) | 2001-07-11 | — | — | CN | disclosed |
| EP-1074543-A1 | AMINOPIPERIDINE DERIVATIVES AS INTEGRIN ALPHA V BETA 3 ANTAGONISTS | MEIJI SEIKA KAISHA LTD. (JP) | 2001-02-07 | — | — | EP | disclosed |