Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 12/20 | 0.53 |
| ▸ | DRD3 | P35462 | 12/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | CHKA | P35790 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | ME3 | Q16798 | 1/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL383016 | 0.80 | DRD2 (0.55) | DRD2DRD3MAPK1KDM4EGAA | |
| SCHEMBL383328 | 0.78 | DRD2 (0.51) | DRD2DRD3MAPK1KDM4EGAA | |
| SCHEMBL383329 | 0.78 | DRD2 (0.51) | DRD2DRD3MAPK1 | |
| SCHEMBL383037 | 0.78 | DRD2 (0.53) | DRD2DRD3MAPK1KDM4EGAA | |
| SCHEMBL382510 | 0.75 | NOS2 (0.51) | DRD2DRD3MAPK1KDM4E | |
| SCHEMBL7655504 | 0.74 | MAPT (0.62) | KDM4EGAACHKA | |
| SCHEMBL27474182 | 0.72 | NAAA (0.50) | DRD3MAPK1 | |
| SCHEMBL6796554 | 0.72 | ITGB3 (0.49) | DRD2DRD3EPHX2 | |
| SCHEMBL6796559 | 0.72 | CASR (0.45) | DRD2DRD3EPHX2ME3 | |
| SCHEMBL383181 | 0.72 | CASR (0.54) | DRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1074543-B1 | AMINOPIPERIDINE DERIVATIVES AS INTEGRIN ALPHA V BETA 3 ANTAGONISTS | MEIJI SEIKA PHARMA CO LTD (JP) | 2012-01-25 | — | — | EP | disclosed |
| US-6420558-B1 | COMPOUNDS WITH AMIDINE GROUPS ANTAGONISTIC ACTIVITY, CELL ADHESION INHIBITORY ACTIVITY, HUMAN PLATELET AGGREGATION INHIBITORY ACTIVITY, AND THERAPEUTIC AGENTS | MEIJI SEIKA KAISHA, LTD. (JP) | 2002-07-16 | — | — | US | disclosed |
| EP-1074543-A1 | AMINOPIPERIDINE DERIVATIVES AS INTEGRIN ALPHA V BETA 3 ANTAGONISTS | MEIJI SEIKA KAISHA LTD. (JP) | 2001-02-07 | — | — | EP | disclosed |