Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 3/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13714429 | 0.93 | ALDH1A1 (0.34) | ALDH1A1NPSR1L3MBTL1MAPTMAPK1 | |
| SCHEMBL13646821 | 0.84 | HTR1A (0.31) | ALDH1A1NPSR1 | |
| SCHEMBL3839764 | 0.80 | L3MBTL1 (0.32) | ALDH1A1L3MBTL1MAPTMAPK1HSD11B1 | |
| SCHEMBL1841672 | 0.77 | WDR5 (0.39) | ALDH1A1NPSR1L3MBTL1 | |
| SCHEMBL3840205 | 0.74 | DRD2 (0.33) | — | |
| Hydrochloric Acid SCHEMBL20336233 | 0.73 | HTR1A (0.32) | — | |
| Hydrochloric Acid SCHEMBL3858187 | 0.73 | HTR1A (0.32) | — | |
| SCHEMBL1843660 | 0.73 | CYP1A2 (0.44) | ALDH1A1NPSR1L3MBTL1MAPTMAPK1 | |
| SCHEMBL3837853 | 0.72 | MAPT (0.46) | MAPT | |
| SCHEMBL13714470 | 0.70 | CYP3A4 (0.38) | L3MBTL1MAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2790660-B1 | CATIONIC TETRAHYDROPYRAZOLOPYRIDINES, DYE COMPOSITION COMPRISING SUCH OXIDATION BASES, IMPLEMENTATION PROCESS THEREFOR AND USE THEREOF | ORÉAL L (FR) | 2016-03-23 | — | — | EP | disclosed |
| US-9078828-B2 | Cationic tetrahydropyrazolopyridines, dye composition comprising such oxidation bases, implementation process therefor and use thereof | L'OREAL (FR) | 2015-07-14 | — | — | US | disclosed |
| US-20140352715-A1 | CATIONIC TETRAHYDROPYRAZOLOPYRIDINES, DYE COMPOSITION COMPRISING SUCH OXIDATION BASES, IMPLEMENTATION PROCESS THEREFOR AND USE THEREOF | L'OREAL (FR) | 2014-12-04 | — | — | US | disclosed |
| EP-1792903-B1 | Composition for the dyeing of keratin fibres comprising at least one cationic 3-amino-pyrazolopyridine derivative | OREAL (FR) | 2009-10-14 | — | — | EP | disclosed |
| US-7578855-B2 | Composition for dyeing keratin fibers comprising at least one cationic 3-amino-pyrazolopyridine derivative, and methods of use thereof | L'ORéAL S.A. (FR) | 2009-08-25 | — | — | US | disclosed |
| US-20070136959-A1 | Composition for dyeing keratin fibers comprising at least one cationic 3-amino-pyrazolopyridine derivative, and methods of use thereof | L'OREAL S.A. (FR) | 2007-06-21 | — | — | US | disclosed |
| EP-1792903-A1 | Composition for the dyeing of keratin fibres comprising at least one cationic 3-amino-pyrazolopyridine derivative | L'OREAL (FR) | 2007-06-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070136959-A1 | Composition for dyeing keratin fibers comprising at least one cationic 3-amino-pyrazolopyridine derivative, and methods of use thereof | KRT18, COX5A, PNPO | ALDH1A1 264/4885NPSR1 4324/4885L3MBTL1 4824/4885 |
| US-20140352715-A1 | CATIONIC TETRAHYDROPYRAZOLOPYRIDINES, DYE COMPOSITION COMPRISING SUCH OXIDATION BASES, IMPLEMENTATION PROCESS THEREFOR AND USE THEREOF | KRT18, HADHB, PPIF | ALDH1A1 698/4885NPSR1 3635/4885L3MBTL1 4853/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.