Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 5/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | NOS2 | P35228 | 1/20 | 0.41 |
| ▸ | WDR5 | P61964 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL44576 | 0.76 | WDR5 (0.46) | ALDH1A1KDM4EMAPTSMN1; SMN2WDR5 | |
| SCHEMBL38703 | 0.75 | WDR5 (0.44) | ALDH1A1KDM4EHPGDWDR5 | |
| SCHEMBL39537 | 0.74 | WDR5 (0.46) | ALDH1A1KDM4EMAPTHPGDHSD17B10 | |
| SCHEMBL38565 | 0.74 | WDR5 (0.44) | ALDH1A1KDM4ENPC1ATMHPGD | |
| SCHEMBL39240 | 0.72 | BTK (0.43) | ALDH1A1KDM4EMEN1KMT2AHPGD | |
| SCHEMBL44622 | 0.72 | LMNA (0.50) | ALDH1A1KDM4EMAPTNPC1MEN1 | |
| SCHEMBL44301 | 0.71 | WDR5 (0.66) | ALDH1A1KDM4ENPC1HPGDHSD17B10 | |
| SCHEMBL38716 | 0.71 | FBP1 (0.47) | ALDH1A1KDM4EMAPTSMN1; SMN2WDR5 | |
| SCHEMBL44216 | 0.71 | WDR5 (0.52) | NPC1HPGDLMNAWDR5 | |
| SCHEMBL44512 | 0.69 | WDR5 (0.52) | KDM4EMAPTNPC1LMNAWDR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011137587-A1 | CYTOKINE INHIBITORS | HUTCHISON MEDIPHARMA LIMITED (CN) | 2011-11-10 | — | — | WO | claimed |
| WO-2011137587-A1 | CYTOKINE INHIBITORS | HUTCHISON MEDIPHARMA LIMITED (CN) | 2011-11-10 | — | — | WO | disclosed |
| WO-2011137587-A1 | CYTOKINE INHIBITORS | HUTCHISON MEDIPHARMA LIMITED (CN) | 2011-11-10 | — | — | WO | disclosed |