SCHEMBL384694

SCHEMBL384694

COC(=O)c1cc(C(=O)OC)n(-c2ncccc2Cl)n1

nearest known ligand 0.47

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.45
MEN1 O00255 1/20 0.41
NPC1 O15118 1/20 0.41
RAB9A P51151 1/20 0.41
KMT2A Q03164 1/20 0.41
MALT1 Q9UDY8 5/20 0.40
RBP4 P02753 1/20 0.40
RXRA P19793 1/20 0.39
NR1H2 P55055 1/20 0.39
NR1H3 Q13133 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.38
ALOX15 P16050 1/20 0.38
HTT P42858 1/20 0.38
CYP1A2 P05177 1/20 0.38
PKM P14618 1/20 0.38
CYP2C19 P33261 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL45318 0.92 KMT2A (0.41) ALDH1A1MEN1KMT2AMALT1RBP4
SCHEMBL23249321 0.87 DHODH (0.45) ALDH1A1MALT1RBP4ALOX15HTT
SCHEMBL44760 0.87 MALT1 (0.39) ALDH1A1MALT1RBP4SMN1; SMN2ALOX15
SCHEMBL29504162 0.87 DHODH (0.45) ALDH1A1MALT1RBP4ALOX15HTT
SCHEMBL421559 0.85 MALT1 (0.38) ALDH1A1MEN1NPC1RAB9AKMT2A
SCHEMBL45109 0.85 MALT1 (0.38) ALDH1A1MALT1RBP4ALOX15HTT
SCHEMBL340847 0.85 MALT1 (0.38) ALDH1A1MEN1NPC1RAB9AKMT2A
SCHEMBL2623669 0.85 MALT1 (0.39) ALDH1A1MEN1NPC1RAB9AKMT2A
SCHEMBL30206595 0.85 MALT1 (0.38) ALDH1A1MEN1NPC1RAB9AKMT2A
SCHEMBL16014672 0.84 MALT1 (0.37) ALDH1A1MEN1NPC1RAB9AKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8946236-B2 Anthranilic acid diamide derivative with hetero-aromatic and hetero-cyclic substituents BAYER CROPSCIENCE AG (DE) 2015-02-03 US disclosed
US-20130324560-A1 ANTHRANILIC ACID DIAMIDE DERIVATIVE WITH HETERO-AROMATIC AND HETERO-CYCLIC SUBSTITUENTS BAYER CROPSCIENCE AG (DE) 2013-12-05 US disclosed
US-8536092-B2 Anthranilic acid diamide derivative with hetero-aromatic and hetero-cyclic substituents BAYER CROPSCIENCE AG (DE) 2013-09-17 US disclosed
US-20120094830-A1 ANTHRANILIC ACID DIAMIDE DERIVATIVE WITH HETERO-AROMATIC AND HETERO-CYCLIC SUBSTITUENTS BAYER CROPSCIENCE AG (DE) 2012-04-19 US disclosed
US-8101550-B2 Anthranilic acid diamide derivative with hetero-aromatic and hetero-cyclic substituents BAYER CROPSCIENCE AG (DE) 2012-01-24 US disclosed
US-20100029478-A1 ANTHRANILIC ACID DIAMIDE DERIVATIVE WITH HETERO-AROMATIC AND HETERO-CYCLIC SUBSTITUENTS BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2010-02-04 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100029478-A1 ANTHRANILIC ACID DIAMIDE DERIVATIVE WITH HETERO-AROMATIC AND HETERO-CYCLIC SUBSTITUENTS DDT, ANTXR2, QDPR ALDH1A1 2028/4885MEN1 1727/4885NPC1 4850/4885
US-20120094830-A1 ANTHRANILIC ACID DIAMIDE DERIVATIVE WITH HETERO-AROMATIC AND HETERO-CYCLIC SUBSTITUENTS DDT, ANTXR2, QDPR ALDH1A1 2028/4885MEN1 1727/4885NPC1 4850/4885
US-20130324560-A1 ANTHRANILIC ACID DIAMIDE DERIVATIVE WITH HETERO-AROMATIC AND HETERO-CYCLIC SUBSTITUENTS DDT, ANTXR2, QDPR ALDH1A1 2028/4885MEN1 1727/4885NPC1 4850/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.