Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | ADRB3 | P13945 | 4/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.39 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.39 |
| ▸ | ECE1 | P42892 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HRH1 | P35367 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | NOS2 | P35228 | 1/20 | 0.34 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25653945 | 0.98 | SLC6A3 (0.50) | SLC6A3KCNH2HDAC1HDAC6ALDH1A1 | |
| SCHEMBL6235049 | 0.98 | KCNH2 (0.50) | SLC6A3KCNH2HDAC1HDAC6ALDH1A1 | |
| SCHEMBL21699960 | 0.94 | SLC6A3 (0.52) | SLC6A3KCNH2HDAC1HDAC6ALDH1A1 | |
| SCHEMBL28578070 | 0.92 | SLC6A3 (0.46) | SLC6A3KCNH2HDAC1HDAC6ALDH1A1 | |
| SCHEMBL2821735 | 0.90 | SLC6A3 (0.47) | SLC6A3KCNH2HDAC1HDAC6ALDH1A1 | |
| SCHEMBL19197711 | 0.90 | KCNH2 (0.46) | SLC6A3KCNH2HDAC1HDAC6ALDH1A1 | |
| SCHEMBL14226438 | 0.89 | KCNH2 (0.48) | SLC6A3KCNH2HDAC1HDAC6ALDH1A1 | |
| SCHEMBL31317623 | 0.89 | SLC6A3 (0.46) | SLC6A3KCNH2ALDH1A1ADRB3ADRB2 | |
| SCHEMBL30665041 | 0.88 | SLC6A3 (0.51) | SLC6A3KCNH2HDAC1HDAC6ALDH1A1 | |
| SCHEMBL5251412 | 0.87 | KCNH2 (0.43) | SLC6A3KCNH2HDAC1HDAC6ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 77 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105712988-A | 2-amino-4,5-diaryl-thiazole-type compound and preparing method and application thereof | 吉首大学 | 2016-06-29 | — | — | CN | claimed |
| US-20240165148-A1 | HYALURONIC ACID-CONJUGATED DIPALMITOYL PHOSPHATIDYL ETHANOLAMINE IN COMBINATION WITH NON-STEROIDAL ANTI-INFLAMMATORY DRUGS (NSAIDS) FOR TREATING OR ALLEVIATING INFLAMMATORY DISEASES | YEDGAR SAUL (IL) | 2024-05-23 | — | — | US | disclosed |
| US-20230119547-A1 | DI-SUBSTITUTED PYRAZOLE COMPOUNDS FOR THE TREATMENT OF DISEASES | FGH BIOTECH INC (US) | 2023-04-20 | — | — | US | disclosed |
| CN-110072861-B | Disubstituted pyrazoles for the treatment of diseases | FGH生物科技公司 | 2022-11-11 | — | — | CN | disclosed |
| US-11339142-B2 | Di-substituted pyrazole compounds for the treatment of diseases | FGH BIOTECH, INC. (US) | 2022-05-24 | — | — | US | disclosed |
| CN-109476635-B | Disubstituted pyrazoles for treatment of diseases | FGH生物科技公司 | 2021-07-13 | — | — | CN | disclosed |
| CN-110204507-B | Process for producing 2-aryl-4-alkylthiazole compound | 浙江大学 | 2021-03-02 | — | — | CN | disclosed |
| CN-111727040-A | Synergistic combination of urolithins A and B for improving cognitive ability or function | 纳特雷恩公司 | 2020-09-29 | — | — | CN | disclosed |
| CN-110204507-A | The preparation method of 2- aryl -4- hydrocarbyl thiazole compound | 浙江大学 | 2019-09-06 | — | — | CN | disclosed |
| EP-3510027-A1 | DI-SUBSTITUTED PYRAZOLE COMPOUNDS FOR THE TREATMENT OF DISEASES | FGH Biotech, Inc. (US) | 2019-07-17 | — | — | EP | disclosed |
| US-6277873-B1 | CONTROLLING DRUG RESISTANT FUNGI | YU DINGWEI TIM (US) | 2001-08-21 | — | — | US | disclosed |
| US-20010000512-A1 | Novel class of piperazino substituted thiazoles | YU DINGWEI TIM (US) | 2001-04-26 | — | — | US | disclosed |
| US-20010000177-A1 | Novel class of thiomorpholino substituted thiazoles | YU DINGWEI TIM (US) | 2001-04-05 | — | — | US | disclosed |
| US-20010000178-A1 | PYRIDYL SUBSTITUTED THIAZOLES | YU DINGWEI TIM (US) | 2001-04-05 | — | — | US | disclosed |
| US-6156776-A | Diaryl substituted thiazoles useful in the treatment of fungal infections | YU DINGWEI TIM (US) | 2000-12-05 | — | — | US | disclosed |
| US-4322428-A | 2(4-Fluorophenyl)-4,5,-bis(4-methoxyphenyl)thiazole and method of use | ELI LILLY AND COMPANY (US) | 1982-03-30 | — | — | US | disclosed |
| EP-0037274-A1 | Substituted triaryl thiazole compounds | ELI LILLY AND COMPANY (US) | 1981-10-07 | — | — | EP | disclosed |
| US-4197306-A | CONTROL OF INSECTS AND ACARIDS | UNIROYAL, INC. (US) | 1980-04-08 | — | — | US | disclosed |
| US-4153703-A | Method of controlling insects and acarids with certain aryl-substituted thiazoles | UNIROYAL, INC. (US) | 1979-05-08 | — | — | US | disclosed |
| US-4127663-A | Thiazole derivatives to treat inflammation | JOHN WYETH & BROTHER LIMITED (GB) | 1978-11-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11339142-B2 | Di-substituted pyrazole compounds for the treatment of diseases | SREBF1, SREBF2, CYP27A1 | SLC6A3 4502/4885KCNH2 4787/4885HDAC1 261/4885 |
| US-20240165148-A1 | HYALURONIC ACID-CONJUGATED DIPALMITOYL PHOSPHATIDYL ETHANOLAMINE IN COMBINATION WITH NON-STEROIDAL ANTI-INFLAMMATORY DRUGS (NSAIDS) FOR TREATING OR ALLEVIATING INFLAMMATORY DISEASES | HPSE, NAPEPLD, PHOSPHO1 | SLC6A3 1603/4885KCNH2 3645/4885HDAC1 1013/4885 |
| US-20010000177-A1 | Novel class of thiomorpholino substituted thiazoles | THUMPD1, ERG28, THOC2 | SLC6A3 1467/4885KCNH2 4171/4885HDAC1 599/4885 |
| US-20230119547-A1 | DI-SUBSTITUTED PYRAZOLE COMPOUNDS FOR THE TREATMENT OF DISEASES | SREBF1, SREBF2, CYP27A1 | SLC6A3 4502/4885KCNH2 4787/4885HDAC1 261/4885 |
| US-20010000512-A1 | Novel class of piperazino substituted thiazoles | ERG28, DPM1, NAT1 | SLC6A3 4208/4885KCNH2 3607/4885HDAC1 92/4885 |
| US-20010000178-A1 | PYRIDYL SUBSTITUTED THIAZOLES | PDXK, OXA1L, ERG28 | SLC6A3 3643/4885KCNH2 4018/4885HDAC1 502/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.