Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | ATM | Q13315 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HK1 | P19367 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3853610 | 0.77 | TP53 (0.46) | ALDH1A1LMNAHSD17B10HPGDMAPT | |
| SCHEMBL27973121 | 0.77 | CNR2 (0.35) | ALDH1A1LMNAHSD17B10CYP2C19HPGD | |
| SCHEMBL3852280 | 0.74 | PARP1 (0.42) | CYP11B2PARP1ALDH1A1LMNAHSD17B10 | |
| SCHEMBL21975440 | 0.73 | GPR3 (0.44) | ALDH1A1MAPTNPC1HTTRAB9A | |
| SCHEMBL10067380 | 0.73 | CYP11B2 (0.68) | CYP11B2ALDH1A1LMNAHSD17B10CYP2C19 | |
| SCHEMBL12103427 | 0.71 | ALDH1A1 (0.42) | CYP11B2ALDH1A1LMNAHSD17B10CYP2C19 | |
| SCHEMBL18566674 | 0.69 | GPR3 (0.58) | ALDH1A1HSD17B10HPGDMAPTL3MBTL1 | |
| SCHEMBL3852371 | 0.69 | CYP11B2 (0.47) | CYP11B2ALDH1A1LMNAHSD17B10CYP2C19 | |
| SCHEMBL28186733 | 0.68 | ALDH1A1 (0.57) | CYP11B2ALDH1A1LMNAHSD17B10CYP2C19 | |
| SCHEMBL28811227 | 0.68 | CYP11B2 (0.56) | CYP11B2ALDH1A1LMNAHSD17B10CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582773-B2 | Substituted phenyl indoles | WYETH (US) | 2009-09-01 | — | — | US | disclosed |
| US-20050070592-A1 | Substituted phenyl indoles | WYETH (US) | 2005-03-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050070592-A1 | Substituted phenyl indoles | TPH2, IDO2, AANAT | CYP11B2 141/4885PARP1 473/4885ALDH1A1 423/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.