Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | RET | P07949 | 1/20 | 0.40 |
| ▸ | MMP3 | P08254 | 1/20 | 0.39 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.39 |
| ▸ | ESR1 | P03372 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3855882 | 0.83 | L3MBTL1 (0.47) | PARP1ALDH1A1KDM4EGAALMNA | |
| SCHEMBL3855188 | 0.80 | ESR1 (0.44) | HSD17B10ALDH1A1HPGDESR2ESR1 | |
| SCHEMBL3852458 | 0.79 | FABP4 (0.53) | CYP2C19ALDH1A1KDM4ELMNASMN1; SMN2 | |
| SCHEMBL3852489 | 0.76 | ALDH1A1 (0.37) | PARP1HSD17B10ALDH1A1HPGDESR1 | |
| SCHEMBL3860742 | 0.76 | FAAH (0.51) | HSD17B10CYP2C19ALDH1A1HPGDKDM4E | |
| SCHEMBL27653131 | 0.76 | RET (0.56) | HSD17B10CYP2C19HSD11B1ALDH1A1HPGD | |
| SCHEMBL3853659 | 0.74 | CYP11B2 (0.41) | PARP1HSD17B10CYP2C19HSD11B1ALDH1A1 | |
| SCHEMBL3853196 | 0.73 | RAB9A (0.35) | PARP1HPGDKDM4EGAASMN1; SMN2 | |
| SCHEMBL3856953 | 0.72 | ESR1 (0.52) | HSD17B10CYP2C19ALDH1A1HPGDMMP3 | |
| SCHEMBL27673093 | 0.72 | RET (0.42) | HSD11B1HPGDRETESR2ESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582773-B2 | Substituted phenyl indoles | WYETH (US) | 2009-09-01 | — | — | US | disclosed |
| US-20050070592-A1 | Substituted phenyl indoles | WYETH (US) | 2005-03-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050070592-A1 | Substituted phenyl indoles | TPH2, IDO2, AANAT | PARP1 473/4885HSD17B10 2232/4885CYP2C19 433/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.