Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | CKS1B | P61024 | 1/20 | 0.37 |
| ▸ | SKP1 | P63208 | 1/20 | 0.37 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19948679 | 0.89 | SIGMAR1 (0.40) | GAATSHRSMN1; SMN2MAPTL3MBTL1 | |
| SCHEMBL31122973 | 0.83 | CTSK (0.35) | GAATSHRSMN1; SMN2MAPTL3MBTL1 | |
| SCHEMBL30229980 | 0.80 | KMT2A (0.40) | TSHRSMN1; SMN2L3MBTL1MEN1KMT2A | |
| SCHEMBL16351364 | 0.79 | ALDH1A1 (0.43) | GAASMN1; SMN2MAPTALDH1A1HPGD | |
| SCHEMBL28606626 | 0.77 | KDM4E (0.36) | GAATSHRSMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL30426841 | 0.77 | ALDH1A1 (0.47) | SMN1; SMN2L3MBTL1ALDH1A1HPGDMEN1 | |
| SCHEMBL31252137 | 0.76 | ATM (0.43) | GAATSHRSMN1; SMN2MAPTL3MBTL1 | |
| SCHEMBL28410516 | 0.76 | GAA (0.42) | GAATSHRSMN1; SMN2MAPTL3MBTL1 | |
| SCHEMBL10437828 | 0.75 | USP2 (0.43) | GAATSHRMAPTL3MBTL1ALDH1A1 | |
| SCHEMBL31033327 | 0.74 | THRB (0.43) | TSHRSMN1; SMN2MAPTALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260132143-A1 | HETEROCYCLIC INHIBITORS OF KRAS G12C MUTANT PROTEINS AND USES THEREOF | AMGEN INC. (US) | 2026-05-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260132143-A1 | HETEROCYCLIC INHIBITORS OF KRAS G12C MUTANT PROTEINS AND USES THEREOF | KRAS, NRAS, HRAS | GAA 3816/4885TSHR 4091/4885SMN1; SMN2 2043/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.