Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 3/20 | 0.68 |
| ▸ | HTR3A | P46098 | 3/20 | 0.68 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.68 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.68 |
| ▸ | HTR3B | O95264 | 1/20 | 0.68 |
| ▸ | DRD2 | P14416 | 1/20 | 0.68 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.68 |
| ▸ | DRD3 | P35462 | 1/20 | 0.68 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.68 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.68 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.68 |
| ▸ | LMNA | P02545 | 1/20 | 0.66 |
| ▸ | MAPT | P10636 | 1/20 | 0.66 |
| ▸ | HTR1A | P08908 | 5/20 | 0.59 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.59 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.59 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.59 |
| ▸ | HTR7 | P34969 | 2/20 | 0.56 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.56 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3951002 | 1.00 | HTR6 (0.68) | HTR6HTR3AADRB1HTR3EHTR3B | |
| SCHEMBL30159754 | 1.00 | HTR6 (0.68) | HTR6HTR3AADRB1HTR3EHTR3B | |
| Hydrochloric Acid SCHEMBL4519236 | 0.98 | LMNA (0.69) | HTR6HTR3AADRB1HTR3EHTR3B | |
| SCHEMBL14984402 | 0.94 | HTR6 (0.60) | HTR6HTR3AADRB1HTR3EHTR3B | |
| Hydrochloric Acid SCHEMBL246152 | 0.93 | LMNA (0.61) | HTR6HTR3AADRB1HTR3EHTR3B | |
| Ethylamine SCHEMBL7690866 | 0.93 | HTR6 (0.59) | HTR6HTR3AADRB1HTR3EHTR3B | |
| Fumaric Acid SCHEMBL3873157 | 0.88 | HTR6 (0.54) | HTR6HTR3AADRB1HTR3EHTR3B | |
| Fumaric Acid SCHEMBL7648541 | 0.88 | HTR6 (0.54) | HTR6HTR3AADRB1HTR3EHTR3B | |
| Fumaric Acid SCHEMBL3873156 | 0.88 | HTR6 (0.54) | HTR6HTR3AADRB1HTR3EHTR3B | |
| Fumaric Acid SCHEMBL7650493 | 0.88 | HTR6 (0.54) | HTR6HTR3AADRB1HTR3EHTR3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 154 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108530391-B | Amide aryl piperazine derivative and preparation method and application thereof | 袁牧 | 2022-05-17 | — | — | CN | claimed |
| US-7560459-B2 | Substituted sulfamate anticonvulsant derivatives | JANSSEN PHARMACEUTICA, N.V. (BE) | 2009-07-14 | — | — | US | claimed |
| US-7060725-B2 | Substituted sulfamate anticonvulsant derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-06-13 | — | — | US | claimed |
| US-20060058373-A1 | Novel substituted sulfamate anticonvulsant derivatives | ABDEL-MAGID AHMED | 2006-03-16 | — | — | US | claimed |
| CN-1665828-A | Novel substituted sulfamate anticonvulsant derivatives | ORTHO MCNEIL PHARM INC (US) | 2005-09-07 | — | — | CN | claimed |
| EP-1506212-A2 | NOVEL SUBSTITUTED SULFAMATE ANTICONVULSANT DERIVATIVES | Ortho-McNeil Pharmaceutical, Inc. (US) | 2005-02-16 | — | — | EP | claimed |
| US-20040038911-A1 | Novel substituted sulfamate anticonvulsant derivatives | JANSSEN PHARMACEUTICA, N.V. (BE) | 2004-02-26 | — | — | US | claimed |
| WO-2003097656-A2 | NOVEL SUBSTITUTED SULFAMATE ANTICONVULSANT DERIVATIVES | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2003-11-27 | — | — | WO | claimed |
| CN-108530391-B | Amide aryl piperazine derivative and preparation method and application thereof | 袁牧 | 2022-05-17 | — | — | CN | disclosed |
| EP-2509600-B1 | THERAPEUTICALLY ACTIVE COMPOUNDS FOR USE IN THE TREATMENT OF CANCER CHARACTERIZED AS HAVING AN IDH MUTATION | AGIOS PHARMACEUTICALS INC (US) | 2017-08-02 | — | — | EP | disclosed |
| US-8883796-B2 | Biphenyl derivatives, pharmaceutical composition comprising the same, and preparation method thereof | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2014-11-11 | — | — | US | disclosed |
| US-20140228568-A1 | BIPHENYL DERIVATIVES, PHARMACEUTICAL COMPOSITION COMPRISING THE SAME, AND PREPARATION METHOD THEREOF | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2014-08-14 | — | — | US | disclosed |
| US-20090312344-A1 | ARYLPIPERAZINE DERIVATIVES AS ADRENERGIC RECEPTOR ANTAGONISTS | RANBAXY LABORATORIES LIMITED (IN) | 2009-12-17 | — | — | US | disclosed |
| US-7560459-B2 | Substituted sulfamate anticonvulsant derivatives | JANSSEN PHARMACEUTICA, N.V. (BE) | 2009-07-14 | — | — | US | disclosed |
| US-4563458-A | CIRCULATORY SYSTEM DISORDERS | BAYER AKTIENGESELLSCHAFT (DE) | 1986-01-07 | — | — | US | disclosed |
| US-4547505-A | ANTIULCER, ANTIPHLOGISTIC, AND ANTISECRETORY AGENT | DEGUSSA AKTIENGESELLSCHAFT (DE) | 1985-10-15 | — | — | US | disclosed |
| EP-0114374-A1 | Substituted 4-aminomethylene chromans or chromenes, process for their preparation and their use in medicines | BAYER AG (DE) | 1984-08-01 | — | — | EP | disclosed |
| US-4438115-A | PIPERAZINE DERIVATIVES | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 1984-03-20 | — | — | US | disclosed |
| EP-0042162-B1 | COMPOSITIONS FOR TREATING DISEASES IN CIRCULATORY ORGANS | Chugai Seiyaku Kabushiki Kaisha (JP) | 1983-11-23 | — | — | EP | disclosed |
| EP-0042162-A2 | Compositions for treating diseases in circulatory organs | Chugai Seiyaku Kabushiki Kaisha (JP) | 1981-12-23 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040038911-A1 | Novel substituted sulfamate anticonvulsant derivatives | SULT1E1, SULT2A1, GRIK5 | HTR6 1250/4885HTR3A 1482/4885ADRB1 2832/4885 |
| US-20140228568-A1 | BIPHENYL DERIVATIVES, PHARMACEUTICAL COMPOSITION COMPRISING THE SAME, AND PREPARATION METHOD THEREOF | HTR7, HTR6, HTR3B | HTR6 2/4885HTR3A 7/4885ADRB1 84/4885 |
| US-20090312344-A1 | ARYLPIPERAZINE DERIVATIVES AS ADRENERGIC RECEPTOR ANTAGONISTS | ADRA1D, ADRB1, ADRA1A | HTR6 236/4885HTR3A 54/4885ADRB1 2/4885 |
| US-20060058373-A1 | Novel substituted sulfamate anticonvulsant derivatives | SULT1E1, CACNA1A, SULT2A1 | HTR6 1446/4885HTR3A 1425/4885ADRB1 2881/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.