Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSIP1 | O75475 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 6/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | RORC | P51449 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5647594 | 0.82 | PSIP1 (0.46) | PSIP1ALDH1A1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL28906881 | 0.80 | CA2 (0.53) | PSIP1ALDH1A1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL3882769 | 0.80 | PSIP1 (0.74) | PSIP1ALDH1A1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL3060869 | 0.80 | PSIP1 (0.47) | PSIP1ALDH1A1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL1941301 | 0.80 | PSIP1 (0.47) | PSIP1ALDH1A1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL10619867 | 0.79 | ALDH1A1 (0.47) | PSIP1ALDH1A1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL5325324 | 0.77 | CA2 (0.56) | PSIP1ALDH1A1CA2SMN1; SMN2KMT2A | |
| SCHEMBL92881 | 0.77 | ALDH1A1 (0.72) | ALDH1A1CYP3A4CYP2C9CYP2C19CA2 | |
| SCHEMBL165901 | 0.76 | ALDH1A1 (0.58) | ALDH1A1CA2GAAKMT2ARORC | |
| SCHEMBL20709277 | 0.76 | ALDH1A1 (0.50) | PSIP1ALDH1A1CYP3A4CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7482356-B2 | Bicyclic pyrazolone cytokine inhibitors | THE PROCTER & GAMBLE COMPANY (US) | 2009-01-27 | — | — | US | claimed |
| JP-2007510739-A | — | — | 2007-04-26 | — | — | JP | claimed |
| EP-1682551-A2 | BICYCLIC PYRAZOLONE CYTOKINE INHIBITORS | THE PROCTER & GAMBLE COMPANY (US) | 2006-07-26 | — | — | EP | claimed |
| WO-2005047287-A2 | BICYCLIC PYRAZOLONE CYTOKINE INHIBITORS | THE PROCTER & GAMBLE COMPANY (US) | 2005-05-26 | — | — | WO | claimed |
| US-20050113392-A1 | Bicyclic pyrazolone cytokine inhibitors | THE PROCTER & GAMBLE COMPANY (US) | 2005-05-26 | — | — | US | claimed |
| US-20090069355-A1 | Bicyclic pyrazolone cytokine inhibitors | CLARK MICHAEL PHILIP | 2009-03-12 | — | — | US | disclosed |
| US-7482356-B2 | Bicyclic pyrazolone cytokine inhibitors | THE PROCTER & GAMBLE COMPANY (US) | 2009-01-27 | — | — | US | disclosed |
| US-7368455-B2 | 6,7-Dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines | THE PROCTER & GAMBLE COMPANY (US) | 2008-05-06 | — | — | US | disclosed |
| US-7326714-B2 | 6,7-Dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines | THE PROCTER & GAMBLE COMPANY (US) | 2008-02-05 | — | — | US | disclosed |
| EP-1427728-B1 | 6,7-DIHYDRO-5H-PYRAZOLO 1,2-A PYRAZOL-1-ONES WHICH CONTROL INFLAMMATORY cYTOKINES | PROCTER & GAMBLE (US) | 2007-03-07 | — | — | EP | disclosed |
| US-7087615-B2 | 6,7-dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which provide analgesia | THE PROCTER & GAMBLE COMPANY (US) | 2006-08-08 | — | — | US | disclosed |
| EP-1682551-A2 | BICYCLIC PYRAZOLONE CYTOKINE INHIBITORS | THE PROCTER & GAMBLE COMPANY (US) | 2006-07-26 | — | — | EP | disclosed |
| US-20030225082-A1 | 1,2-dihydropyrazol-3-ones which controls inflammatory cytokines | PROCTER & GAMBLE COMPANY, THE | 2003-12-04 | — | — | US | disclosed |
| WO-2003080184-A1 | 1,2-DIHYDROPYRAZOL-3-ONES AS CYTOKINE MEDIATORS | THE PROCTER & GAMBLE COMPANY (US) | 2003-10-02 | — | — | WO | disclosed |
| US-20030134867-A1 | 6,7-Dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines | THE PROCTER & GAMBLE COMPANY | 2003-07-17 | — | — | US | disclosed |
| US-20030105084-A1 | Compound which inhibit the release of inflammatory cytokines | THE PROCTER & GAMBLE COMPANY | 2003-06-05 | — | — | US | disclosed |
| US-6566357-B1 | To inhibit the extracellular release of inflammatory cytokines; therapy | THE PROCTER & GAMBLE CO. | 2003-05-20 | — | — | US | disclosed |
| WO-2003024973-A1 | SPIROCYCLIC-6,7-DIHYDRO-5H-PYRAZOLO[1,2-A]PYRAZOL-1-ONES WHICH CONTROL INFLAMMATORY CYTOKINES | THE PROCTER & GAMBLE COMPANY (US) | 2003-03-27 | — | — | WO | disclosed |
| WO-2003024971-A1 | 6,7-DIHYDRO-5H-PYRAZOLO[1,2-A]PYRAZOL-1-ONES WHICH CONTROL INFLAMMATORY CYTOKINES | THE PROCTER & GAMBLE COMPANY (US) | 2003-03-27 | — | — | WO | disclosed |
| WO-2003024970-A1 | COMPOUNDS WHICH INHIBIT THE RELEASE OF INFLAMMATORY CYTOKINES | THE PROCTER & GAMBLE COMPANY (US) | 2003-03-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030105084-A1 | Compound which inhibit the release of inflammatory cytokines | IL1B, IL1A, TNF | PSIP1 3766/4885ALDH1A1 221/4885CYP3A4 370/4885 |
| US-20050113392-A1 | Bicyclic pyrazolone cytokine inhibitors | IL1B, IL1A, IL1RN | PSIP1 3291/4885ALDH1A1 385/4885CYP3A4 1560/4885 |
| US-20030134867-A1 | 6,7-Dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines | IL1B, IL6, IL1A | PSIP1 3893/4885ALDH1A1 795/4885CYP3A4 757/4885 |
| US-20030225082-A1 | 1,2-dihydropyrazol-3-ones which controls inflammatory cytokines | IL1B, IL1A, IL1R1 | PSIP1 2783/4885ALDH1A1 122/4885CYP3A4 757/4885 |
| US-20090069355-A1 | Bicyclic pyrazolone cytokine inhibitors | IL1B, IL1A, IL1RN | PSIP1 3291/4885ALDH1A1 385/4885CYP3A4 1560/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.