Sugi Predict

Sugi Predict / Compounds / SCHEMBL388492

SCHEMBL388492

SCHEMBL388492

Cc1nc(S(=O)(=O)Cl)cn1C

nearest known ligand 0.44

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
▸ TDP1 Q9NUW8 1/20 0.44
▸ LMNA P02545 1/20 0.44
▸ THRB P10828 1/20 0.41
▸ NLRP3 Q96P20 1/20 0.39
▸ PTGDR2 Q9Y5Y4 1/20 0.36
▸ KDM4E B2RXH2 1/20 0.35
▸ CYP17A1 P05093 1/20 0.33
▸ S1PR1 P21453 1/20 0.32
▸ TRIM24 O15164 4/20 0.32
▸ ALDH1A1 P00352 1/20 0.32
▸ HCRTR2 O43614 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1641716 0.81 TDP1 (0.45) TDP1LMNATHRBNLRP3PTGDR2
SCHEMBL2702033 0.81 TDP1 (0.45) TDP1LMNATHRBNLRP3PTGDR2
SCHEMBL2399893 0.79 ADORA2A (0.31) —
Hydrochloric Acid SCHEMBL27570535 0.79 TDP1 (0.44) TDP1LMNATHRBNLRP3PTGDR2
SCHEMBL2399888 0.79 TDP1 (0.32) TDP1
SCHEMBL489962 0.79 LMNA (0.48) TDP1LMNATHRBNLRP3PTGDR2
SCHEMBL12922882 0.78 LMNA (0.43) TDP1LMNATHRBNLRP3PTGDR2
SCHEMBL6200154 0.78 LMNA (0.34) TDP1LMNA
SCHEMBL14968743 0.76 LMNA (0.56) TDP1LMNATHRBNLRP3KDM4E
SCHEMBL13290917 0.76 TDP1 (0.49) TDP1LMNATHRBNLRP3PTGDR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 380 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20100227412-A1 Simultaneous Detection of Estrogen and Non Estrogen Steroids PERKINELMER HEALTH SCIENCES, INC. (US) 2010-09-09 — — US claimed
WO-2010010559-A1 CONTROLLED HYDROGEN GENERATION, STORAGE AND TRANSPORTATION SOLUTION M.I.H.G. LTD. (IL) 2010-01-28 — — WO claimed
US-20100021376-A1 CONTROLLED HYDROGEN GENERATION, STORAGE AND TRANSPORTATION SOLUTION SILBERMAN ALEX 2010-01-28 — — US claimed
US-12630548-B2 Azetidine derivatives for the treatment of integrin associated diseases THE UNIVERSITY OF NOTTINGHAM (GB) 2026-05-19 — — US disclosed
US-20250339388-A1 PHENYLALANINE-BASED LAT1 INHIBITORS AND USES THEREOF MAXYMUNE THERAPEUTICS INC (US) 2025-11-06 — — US disclosed
US-20250319046-A1 PHENYLALANINE-BASED LAT1 INHIBITORS AND USES THEREOF MAXYMUNE THERAPEUTICS INC (US) 2025-10-16 — — US disclosed
US-12427124-B1 Phenylalanine-based LAT1 inhibitors and uses thereof Maxymune Therapeutics, Inc. (US) 2025-09-30 — — US disclosed
US-12391680-B2 Compounds and compositions for the treatment of cystic fibrosis FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA (IT) 2025-08-19 — — US disclosed
EP-3645533-B1 TDO2 AND IDO1 INHIBITORS GENENTECH INC (US) 2025-03-26 — — EP disclosed
CN-113226356-B Activation of pyruvate kinase R 诺沃挪第克健康护理股份公司 2025-03-04 — — CN disclosed
CN-118961985-A Kit and method for simultaneously detecting 18 steroid hormones based on double-derivative technology 上海万子健医学检验实验室有限公司 2024-11-15 — — CN disclosed
US-20030144175-A1 Protease inhibitors SMITHKLINE BEECHAM CORPORATION 2003-07-31 — — US disclosed
US-20030013721-A1 Novel piperidine and piperazine derivatives ASTRAZENECA AB (SE) 2003-01-16 — — US disclosed
US-20020147188-A1 Protease inhibitors SMITHKLINE BEECHAM CORPORATION 2002-10-10 — — US disclosed
EP-1242427-A1 NOVEL PIPERIDINE AND PIPERAZINE DERIVATIVES AstraZeneca AB (SE) 2002-09-25 — — EP disclosed
WO-2001046200-A1 NOVEL PIPERIDINE AND PIPERAZINE DERIVATIVES ASTRAZENECA AB (SE) 2001-06-28 — — WO disclosed
EP-0442348-B1 Imidazole compounds, process for preparation, medicaments based on these compounds and some intermediates HOECHST AG (DE) 1996-07-17 — — EP disclosed
US-5356922-A Treatment of disturbances in microcirculation HOECHST AKTIENGESELLSCHAFT (DE) 1994-10-18 — — US disclosed
US-5232922-A Cardiovascular disorders HOECHST AKTIENGESELLSCHAFT (DE) 1993-08-03 — — US disclosed
EP-0442348-A2 Imidazole compounds, process for preparation, medicaments based on these compounds and some intermediates HOECHST AKTIENGESELLSCHAFT (DE) 1991-08-21 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250339388-A1 PHENYLALANINE-BASED LAT1 INHIBITORS AND USES THEREOF SLC43A1, SLC7A1, SLC1A5 TDP1 1176/4885LMNA 4750/4885THRB 1142/4885
US-20030013721-A1 Novel piperidine and piperazine derivatives IL5, VIP, EP300 TDP1 4306/4885LMNA 3352/4885THRB 3320/4885
US-12391680-B2 Compounds and compositions for the treatment of cystic fibrosis CFTR, ABCB11, ABCC5 TDP1 4652/4885LMNA 2999/4885THRB 2128/4885
US-12427124-B1 Phenylalanine-based LAT1 inhibitors and uses thereof SLC43A1, SLC7A1, SLC1A5 TDP1 1176/4885LMNA 4750/4885THRB 1142/4885
US-12630548-B2 Azetidine derivatives for the treatment of integrin associated diseases ITGA2, ITGB2, ITGB1 TDP1 4504/4885LMNA 2493/4885THRB 108/4885
US-20020147188-A1 Protease inhibitors CTSK, MMP13, CTSZ TDP1 1653/4885LMNA 2800/4885THRB 3778/4885
US-20250319046-A1 PHENYLALANINE-BASED LAT1 INHIBITORS AND USES THEREOF SLC43A1, SLC7A1, SLC1A5 TDP1 1176/4885LMNA 4750/4885THRB 1142/4885
US-20030144175-A1 Protease inhibitors CTSK, MMP13, CTSZ TDP1 1653/4885LMNA 2800/4885THRB 3778/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.