Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | SQLE | Q14534 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | MEP1B | Q16820 | 5/20 | 0.42 |
| ▸ | MEP1A | Q16819 | 2/20 | 0.42 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | MMP13 | P45452 | 1/20 | 0.41 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.41 |
| ▸ | TAS2R14 | Q9NYV8 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3879707 | 0.88 | RAB9A (0.53) | HDAC4HDAC6LMNAALDH1A1SQLE | |
| SCHEMBL3876863 | 0.87 | NR1H4 (0.49) | LMNAALDH1A1MAPTSMN1; SMN2MMP13 | |
| SCHEMBL3872157 | 0.87 | PPARG (0.45) | TRPM8HDAC4HDAC6LMNAALDH1A1 | |
| SCHEMBL3872649 | 0.83 | ALDH1A1 (0.49) | LMNAALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL3887293 | 0.83 | MAPT (0.49) | LMNAALDH1A1MAPTSMN1; SMN2RXFP1 | |
| SCHEMBL3872970 | 0.81 | ROCK2 (0.45) | LMNAALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL3880937 | 0.80 | RAB9A (0.52) | LMNAALDH1A1MAPTSMN1; SMN2MMP13 | |
| SCHEMBL3882723 | 0.80 | ALDH1A1 (0.51) | HDAC6LMNAALDH1A1SMN1; SMN2CA2 | |
| SCHEMBL3882913 | 0.79 | LSS (0.48) | LMNAALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL3872842 | 0.78 | POLB (0.53) | LMNAALDH1A1SMN1; SMN2RXFP1MEP1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1814846-B1 | 11BETA-HSD1 INHIBITORS | EVOTEC AG (DE) | 2009-04-08 | — | — | EP | disclosed |
| US-20090069323-A1 | 11beta-hsdi inhibitors | EVOTEC AG (DE) | 2009-03-12 | — | — | US | disclosed |
| EP-1814846-A1 | 11BETA-HSD1 INHIBITORS | Evotec AG (DE) | 2007-08-08 | — | — | EP | disclosed |
| WO-2006048330-A1 | 11ΒΕΤΑ-HSD1 INHIBITORS | EVOTEC AG (DE) | 2006-05-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090069323-A1 | 11beta-hsdi inhibitors | HSD3B1, HSD3B2, HSD11B1 | TRPM8 4838/4885HDAC4 196/4885HDAC6 811/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.