Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.53 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.44 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.44 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.43 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.43 |
| ▸ | SQLE | Q14534 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | LOX | P28300 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3880937 | 0.89 | RAB9A (0.52) | RAB9AMAPTSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL3886237 | 0.88 | TRPM8 (0.49) | SQLEMAPTSMN1; SMN2ALDH1A1RXFP1 | |
| SCHEMBL3872157 | 0.84 | PPARG (0.45) | RAB9ASQLEMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL3887293 | 0.82 | MAPT (0.49) | RAB9AMAPTSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL3876863 | 0.81 | NR1H4 (0.49) | RAB9AMAPTSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL3872649 | 0.81 | ALDH1A1 (0.49) | RAB9ASMN1; SMN2KDM4EALDH1A1LMNA | |
| SCHEMBL3874272 | 0.81 | POLB (0.49) | RAB9ALOXL2CYP4F2CYP4A11MAPT | |
| SCHEMBL3872970 | 0.80 | ROCK2 (0.45) | RAB9AMAPTSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL3882723 | 0.79 | ALDH1A1 (0.51) | SMN1; SMN2ALDH1A1LMNAHDAC6NPC1 | |
| SCHEMBL3877752 | 0.79 | PLAU (0.54) | RAB9ALOXL2NR3C1CYP4F2CYP4A11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1814846-B1 | 11BETA-HSD1 INHIBITORS | EVOTEC AG (DE) | 2009-04-08 | — | — | EP | disclosed |
| US-20090069323-A1 | 11beta-hsdi inhibitors | EVOTEC AG (DE) | 2009-03-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090069323-A1 | 11beta-hsdi inhibitors | HSD3B1, HSD3B2, HSD11B1 | RAB9A 4300/4885LOXL2 2990/4885NR3C1 85/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.