Known targets — ChEMBL curated mechanism
ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO
The experimentally established mechanism targets of Etidronic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FDPS known ✓ | P14324 | 15/20 | 0.45 |
| ▸ | ADRB3 known ✓ | P13945 | 1/20 | 0.32 |
| ▸ | PDE4D known ✓ | Q08499 | 1/20 | 0.32 |
| ▸ | PDE3A known ✓ | Q14432 | 1/20 | 0.32 |
| ▸ | THRB known ✓ | P10828 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.87 |
| ▸ | PGK1 | P00558 | 1/20 | 0.43 |
| ▸ | PGK2 | P07205 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | GGPS1 | O95749 | 7/20 | 0.33 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Etidronic Acid SCHEMBL7743279 | 0.97 | LMNA (0.93) | LMNAFDPSPGK1PGK2CA2 | |
| Etidronic Acid SCHEMBL3896726 | 0.97 | LMNA (0.93) | LMNAFDPSPGK1PGK2CA2 | |
| Etidronic Acid SCHEMBL6850113 | 0.93 | LMNA (0.87) | LMNAFDPSPGK1PGK2CA2 | |
| Etidronic Acid SCHEMBL10705565 | 0.93 | LMNA (0.87) | LMNAFDPSPGK1PGK2CA2 | |
| Etidronic Acid SCHEMBL18607 | 0.93 | LMNA (1.00) | LMNAFDPSPGK1PGK2CA2 | |
| Etidronic Acid SCHEMBL10532992 | 0.93 | LMNA (1.00) | LMNAFDPSPGK1PGK2CA2 | |
| Etidronic Acid SCHEMBL10706705 | 0.90 | LMNA (0.93) | LMNAFDPSPGK1PGK2CA2 | |
| Etidronic Acid SCHEMBL10524952 | 0.90 | LMNA (0.93) | LMNAFDPSPGK1PGK2CA2 | |
| Etidronic Acid SCHEMBL636757 | 0.90 | LMNA (0.93) | LMNAFDPSPGK1PGK2CA2 | |
| Etidronic Acid SCHEMBL17580248 | 0.90 | LMNA (0.93) | LMNAFDPSPGK1PGK2CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3635065-B1 | COMPOSITION | JOTUN AS (NO) | 2024-09-18 | — | — | EP | disclosed |
| US-11254822-B2 | Composition | JOTUN A/S (NO) | 2022-02-22 | — | — | US | disclosed |
| CN-109071866-B | Fine particle coating | 佐敦有限公司 | 2021-07-02 | — | — | CN | disclosed |
| US-20200148891-A1 | Composition | JOTUN A/S (NO) | 2020-05-14 | — | — | US | disclosed |
| EP-3635065-A1 | COMPOSITION | Jotun A/S (NO) | 2020-04-15 | — | — | EP | disclosed |
| CN-110799607-A | Composition comprising a metal oxide and a metal oxide | 佐敦有限公司 | 2020-02-14 | — | — | CN | disclosed |
| US-20190085174-A1 | PARTICULATE COATING | JOTUN A/S (NO) | 2019-03-21 | — | — | US | disclosed |
| WO-2018210849-A1 | COMPOSITION | JOTUN A/S (NO) | 2018-11-22 | — | — | WO | disclosed |
| WO-2017186870-A1 | PARTICULATE COATING | JOTUN A/S (NO) | 2017-11-02 | — | — | WO | disclosed |
| EP-1593716-B1 | Powder coating compositions | AKZO NOBEL COATINGS INT BV (NL) | 2009-02-25 | — | — | EP | disclosed |
| US-7244780-B1 | Powder coating compositions | INTERNATIONAL COATINGS LIMITED (GB) | 2007-07-17 | — | — | US | disclosed |
| EP-1593716-A2 | Powder coating compositions | International Coatings Limited (GB) | 2005-11-09 | — | — | EP | disclosed |
| EP-1129143-B1 | POWDER COATING COMPOSITIONS | INT COATINGS LTD (GB) | 2005-09-14 | — | — | EP | disclosed |
| EP-1129143-A1 | POWDER COATING COMPOSITIONS | International Coatings Limited (GB) | 2001-09-05 | — | — | EP | disclosed |
| WO-2000022053-A1 | POWDER COATING COMPOSITIONS | INTERNATIONAL COATINGS LIMITED (GB) | 2000-04-20 | — | — | WO | disclosed |