Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | RAPGEF4 | Q8WZA2 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3708106 | 0.82 | LMNA (0.52) | LMNAALDH1A1RAPGEF4TSHRHPGD | |
| Hydrochloric Acid SCHEMBL14988832 | 0.82 | LMNA (0.52) | LMNAALDH1A1RAPGEF4TSHRHPGD | |
| SCHEMBL11335323 | 0.81 | LMNA (0.51) | LMNAALDH1A1RAPGEF4TSHRHPGD | |
| SCHEMBL11273478 | 0.80 | DRD2 (0.46) | LMNAALDH1A1MAPTNLRP3POLB | |
| SCHEMBL15516425 | 0.78 | NLRP3 (0.46) | LMNAALDH1A1RAPGEF4TSHRHPGD | |
| SCHEMBL11261894 | 0.78 | PGR (0.38) | LMNATSHRMEN1KMT2AHTT | |
| SCHEMBL5312679 | 0.76 | NLRP3 (0.59) | LMNAALDH1A1TSHRHPGDMAPT | |
| SCHEMBL11261899 | 0.76 | TACR1 (0.32) | LMNAALDH1A1TSHRMEN1KMT2A | |
| SCHEMBL27478662 | 0.74 | LMNA (0.68) | LMNAALDH1A1TSHRHPGDMAPT | |
| SCHEMBL11261326 | 0.74 | RORC (0.34) | HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1730117-B1 | THIOUREA COMPOSITIONS AND USES THEREOF | UNIV HONG KONG (CN) | 2015-12-02 | — | — | EP | disclosed |
| US-20090226422-A1 | Chemical Inhibitors of Inhibitors of Differentiation | ANGIOGENEX | 2009-09-10 | — | — | US | disclosed |
| US-7501510-B2 | Thiourea compositions and uses thereof | THE UNIVERSITY OF HONG KONG (CN) | 2009-03-10 | — | — | US | disclosed |
| US-7501510-B2 | Thiourea compositions and uses thereof | THE UNIVERSITY OF HONG KONG (CN) | 2009-03-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090226422-A1 | Chemical Inhibitors of Inhibitors of Differentiation | BRAF, MAPK1, RAF1 | LMNA 2937/4885ALDH1A1 1860/4885RAPGEF4 332/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.