Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 4/20 | 0.45 |
| ▸ | OPRL1 | P41146 | 4/20 | 0.45 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.37 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.37 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3244904 | 0.84 | CA2 (0.36) | OPRM1OPRL1AOC3TSHRALDH1A1 | |
| SCHEMBL3237718 | 0.82 | DPP4 (0.38) | OPRM1OPRL1AOC3LMNASLC6A2 | |
| SCHEMBL3245048 | 0.80 | SLC6A2 (0.40) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL3233259 | 0.79 | DPP4 (0.38) | OPRM1OPRL1AOC3LMNAADRA2C | |
| SCHEMBL1350777 | 0.79 | DPP4 (0.38) | OPRM1OPRL1AOC3LMNAADRA2C | |
| SCHEMBL3236836 | 0.78 | LMNA (0.40) | OPRM1OPRL1TSHRLMNASLC6A2 | |
| SCHEMBL3232917 | 0.76 | SLC6A2 (0.34) | AOC3LMNASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL3237835 | 0.76 | CHRM2 (0.36) | AOC3SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL3243802 | 0.76 | OPRL1 (0.35) | OPRL1AOC3LMNASLC6A2SLC6A4 | |
| SCHEMBL24434872 | 0.74 | OPRM1 (0.53) | OPRM1OPRL1AOC3TSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7745642-B2 | Glycine transport inhibitors | GLAXO GROUP LIMITED (GB) | 2010-06-29 | — | — | US | disclosed |
| US-7745642-B2 | Glycine transport inhibitors | GLAXO GROUP LIMITED (GB) | 2010-06-29 | — | — | US | disclosed |
| US-20090286828-A1 | 2-AMINO-1-PHENYLETHYLCARBOXAMIDE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 2009-11-19 | — | — | US | disclosed |
| US-20090286828-A1 | 2-AMINO-1-PHENYLETHYLCARBOXAMIDE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 2009-11-19 | — | — | US | disclosed |
| US-20090175788-A1 | RADIOLABELLED LIGAND FOR THE GLYCINE 1 TRANSPORTER | GLAXO GROUP LIMITED (GB) | 2009-07-09 | — | — | US | disclosed |
| US-20090175788-A1 | RADIOLABELLED LIGAND FOR THE GLYCINE 1 TRANSPORTER | GLAXO GROUP LIMITED (GB) | 2009-07-09 | — | — | US | disclosed |
| US-20090175788-A1 | RADIOLABELLED LIGAND FOR THE GLYCINE 1 TRANSPORTER | GLAXO GROUP LIMITED (GB) | 2009-07-09 | — | — | US | disclosed |
| EP-2032512-A1 | RADIOLABELLED LIGAND FOR THE GLYCINE 1 TRANSPORTER | Glaxo Group Limited (GB) | 2009-03-11 | — | — | EP | disclosed |
| US-20080287547-A1 | Glycine Transport Inhibitors | GLAXO GROUP LIMITED (GB) | 2008-11-20 | — | — | US | disclosed |
| US-20080287547-A1 | Glycine Transport Inhibitors | GLAXO GROUP LIMITED (GB) | 2008-11-20 | — | — | US | disclosed |
| WO-2007147838-A1 | RADIOLABELLED LIGAND FOR THE GLYCINE 1 TRANSPORTER | GLAXO GROUP LIMITED (GB) | 2007-12-27 | — | — | WO | disclosed |
| WO-2007147838-A1 | RADIOLABELLED LIGAND FOR THE GLYCINE 1 TRANSPORTER | GLAXO GROUP LIMITED (GB) | 2007-12-27 | — | — | WO | disclosed |
| WO-2006067430-A1 | 2-AMINO-1-PHENYLETHYLCARBOXAMIDE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 2006-06-29 | — | — | WO | disclosed |
| WO-2006067423-A1 | GLYCINE TRANSPORT INHIBITORS | GLAXO GROUP LIMITED (GB) | 2006-06-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090286828-A1 | 2-AMINO-1-PHENYLETHYLCARBOXAMIDE DERIVATIVES | PNMT, SLC18A2, COMT | OPRM1 2201/4885OPRL1 319/4885AOC3 694/4885 |
| US-20080287547-A1 | Glycine Transport Inhibitors | SLC18A2, SLC6A5, SLC1A2 | OPRM1 1531/4885OPRL1 494/4885AOC3 871/4885 |
| US-20090175788-A1 | RADIOLABELLED LIGAND FOR THE GLYCINE 1 TRANSPORTER | SLC7A1, GLRA1, SLC6A5 | OPRM1 400/4885OPRL1 216/4885AOC3 1232/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.