Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TUBB1 | Q9H4B7 | 3/20 | 0.56 |
| ▸ | MAPT | P10636 | 4/20 | 0.55 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.46 |
| ▸ | TUBB | P07437 | 1/20 | 0.46 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.46 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.46 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.46 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.46 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.46 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.46 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.46 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.46 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5520044 | 0.85 | MAPT (0.69) | TUBB1MAPTLMNAHTTSMN1; SMN2 | |
| SCHEMBL6109703 | 0.82 | MAPT (0.81) | MAPTLMNAHTTSMN1; SMN2TP53 | |
| SCHEMBL20355378 | 0.76 | MAPT (0.55) | TUBB1MAPTLMNAHTTSMN1; SMN2 | |
| SCHEMBL5784803 | 0.72 | MAPT (0.78) | MAPTLMNAHTTSMN1; SMN2TP53 | |
| SCHEMBL29441465 | 0.72 | TUBB1 (1.00) | TUBB1MAPTSMN1; SMN2TP53TUBB4A | |
| SCHEMBL565514 | 0.72 | TUBB1 (1.00) | TUBB1MAPTSMN1; SMN2TP53TUBB4A | |
| SCHEMBL28405115 | 0.71 | MAPT (0.65) | MAPTLMNAHTTSMN1; SMN2TP53 | |
| SCHEMBL3916978 | 0.71 | TUBB1 (0.58) | TUBB1PDGFRBTUBB4ATUBBTUBA3C | |
| SCHEMBL3917834 | 0.71 | TUBB4A (0.81) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL5095441 | 0.70 | POLB (0.59) | MAPTLMNAHTTSMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7528165-B2 | Indole compounds | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 2009-05-05 | — | — | US | claimed |
| US-20050267108-A1 | Indole compounds | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 2005-12-01 | — | — | US | claimed |
| US-6933316-B2 | Indole compounds | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 2005-08-23 | — | — | US | claimed |
| EP-1506960-A1 | Indole compounds as inhibitors of tubulin polymerisation for the treatment of angiogenesis-related disorders | National Health Research Institutes (TW) | 2005-02-16 | — | — | EP | claimed |
| US-20030195244-A1 | Indole compounds | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 2003-10-16 | — | — | US | claimed |
| US-7632955-B2 | Indole compounds | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 2009-12-15 | — | — | US | disclosed |
| US-7632955-B2 | Indole compounds | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 2009-12-15 | — | — | US | disclosed |
| US-7632955-B2 | Indole compounds | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 2009-12-15 | — | — | US | disclosed |
| US-7528165-B2 | Indole compounds | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 2009-05-05 | — | — | US | disclosed |
| US-7528165-B2 | Indole compounds | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 2009-05-05 | — | — | US | disclosed |
| US-7528165-B2 | Indole compounds | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 2009-05-05 | — | — | US | disclosed |
| US-20050267108-A1 | Indole compounds | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 2005-12-01 | — | — | US | disclosed |
| US-20050267194-A1 | Indole compounds | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 2005-12-01 | — | — | US | disclosed |
| US-6933316-B2 | Indole compounds | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 2005-08-23 | — | — | US | disclosed |
| EP-1506960-A1 | Indole compounds as inhibitors of tubulin polymerisation for the treatment of angiogenesis-related disorders | National Health Research Institutes (TW) | 2005-02-16 | — | — | EP | disclosed |
| US-20030195244-A1 | Indole compounds | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 2003-10-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050267108-A1 | Indole compounds | TUBB1, TUBB3, TUBB | TUBB1 1/4885MAPT 55/4885PDGFRB 115/4885 |
| US-20050267194-A1 | Indole compounds | TUBB1, TUBB, TUBB3 | TUBB1 1/4885MAPT 165/4885PDGFRB 98/4885 |
| US-20030195244-A1 | Indole compounds | NR2C2, NPSR1, HCRTR2 | TUBB1 921/4885MAPT 3276/4885PDGFRB 1674/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.