SCHEMBL3921079

SCHEMBL3921079

Cl[Si](Cl)(Cl)c1ccccc1C1C2CC3CC(C2)CC1C3

nearest known ligand 0.36

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
SCN9A Q15858 2/20 0.33
ALDH1A1 P00352 1/20 0.32
HTT P42858 1/20 0.32
HSD17B10 Q99714 1/20 0.32
CHRM2 P08172 1/20 0.31
CHRM4 P08173 1/20 0.31
CHRM5 P08912 1/20 0.31
SIGMAR1 Q99720 1/20 0.31
EPHX2 P34913 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5672306 0.74 CYP3A4 (0.38) SCN9AALDH1A1SIGMAR1EPHX2
SCHEMBL28318181 0.72 KDM1A (0.47)
SCHEMBL28174692 0.72 SIGMAR1 (0.41) SCN9ASIGMAR1EPHX2
SCHEMBL10012943 0.72 EPHX2 (0.35) SCN9ASIGMAR1EPHX2
SCHEMBL5346555 0.72 EPHX2 (0.36) SCN9AHSD17B10SIGMAR1EPHX2
SCHEMBL9721529 0.72 HTR2C (0.42) ALDH1A1SIGMAR1
SCHEMBL345589 0.72 HTR2A (0.42) SCN9AALDH1A1HSD17B10EPHX2
SCHEMBL2710116 0.70 ALDH1A1 (0.41) SCN9AALDH1A1HTTHSD17B10EPHX2
SCHEMBL3629131 0.69 KDM1A (0.52) ALDH1A1HSD17B10
SCHEMBL27694917 0.69 CHRNB2 (0.40) ALDH1A1HSD17B10SIGMAR1EPHX2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-2006526672-A 2006-11-24 JP claimed
US-20060180900-A1 Organo-silsesquioxane polymers for forming low-k dielectrics SILECS OY (FI) 2006-08-17 US claimed
WO-2004090019-A1 ORGANO-SILSESQUIOXANE POLYMERS FOR FORMING LOW-K DIELECTRICS SILECS OY (FI) 2004-10-21 WO claimed
US-7622399-B2 Method of forming low-k dielectrics using a rapid curing process SILECS OY (FI) 2009-11-24 US disclosed
US-20090278254-A1 Dielectric materials and methods for integrated circuit applications SILECS OY (FI) 2009-11-12 US disclosed
US-7514709-B2 Organo-silsesquioxane polymers for forming low-k dielectrics SILECS OY (FI) 2009-04-07 US disclosed
US-20070063188-A1 Low-k dielectric material SILECS OY (FI) 2007-03-22 US disclosed
US-20060180900-A1 Organo-silsesquioxane polymers for forming low-k dielectrics SILECS OY (FI) 2006-08-17 US disclosed
US-20050064726-A1 Method of forming low-k dielectrics SILECS OY (FI) 2005-03-24 US disclosed
US-20050032357-A1 Dielectric materials and methods for integrated circuit applications SILECS OY (FI) 2005-02-10 US disclosed
WO-2004090019-A1 ORGANO-SILSESQUIOXANE POLYMERS FOR FORMING LOW-K DIELECTRICS SILECS OY (FI) 2004-10-21 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070063188-A1 Low-k dielectric material KCNH3, KCNH2, KCNN3 SCN9A 127/4885ALDH1A1 2343/4885HTT 4794/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.