SCHEMBL3925835

SCHEMBL3925835

COC(=O)NS(=O)(=O)c1ccc(Cl)cc1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FLT1 P17948 11/20 0.61
FLT4 P35916 11/20 0.61
KDR P35968 11/20 0.61
EGFR P00533 3/20 0.56
ERBB2 P04626 3/20 0.56
L3MBTL1 Q9Y468 1/20 0.56
ALDH1A1 P00352 2/20 0.55
LMNA P02545 1/20 0.55
CYP3A4 P08684 1/20 0.55
THRB P10828 1/20 0.55
TSHR P16473 1/20 0.55
NFKB1 P19838 1/20 0.55
HTR2A P28223 1/20 0.55
CYP2C19 P33261 1/20 0.55
ADRA1A P35348 1/20 0.55
SMN1; SMN2 Q16637 1/20 0.55
NPSR1 Q6W5P4 1/20 0.55
CA1 P00915 2/20 0.55
CA2 P00918 2/20 0.55
CA12 O43570 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10399038 0.86 ALDH1A1 (0.57) FLT1FLT4KDREGFRERBB2
SCHEMBL9526916 0.83 KMT2A (0.69) EGFRALDH1A1LMNANFKB1SMN1; SMN2
SCHEMBL11853703 0.83 FLT1 (0.54) FLT1FLT4KDREGFRERBB2
SCHEMBL6495011 0.83 STS (0.61) FLT1FLT4KDREGFRERBB2
SCHEMBL9128141 0.83 SMN1; SMN2 (0.58) FLT1FLT4KDREGFRERBB2
Asulam SCHEMBL64856 0.81 SMN1; SMN2 (0.68) ALDH1A1LMNATSHRCYP2C19SMN1; SMN2
Asulam SCHEMBL16899633 0.81 SMN1; SMN2 (0.68) ALDH1A1LMNATSHRCYP2C19SMN1; SMN2
SCHEMBL26282718 0.81 MMP2 (0.65) FLT1FLT4KDREGFRERBB2
SCHEMBL3805836 0.81 CA1 (0.55) ALDH1A1LMNATSHRNFKB1SMN1; SMN2
SCHEMBL13329865 0.81 CA1 (0.59) EGFRERBB2L3MBTL1ALDH1A1CA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250248973-A1 CANNABINOID RECEPTOR 1 ANTAGONISTS/INVERSE AGONISTS AND USES THEREOF CORBUS PHARMACEUTICALS, INC. 2025-08-07 US disclosed
US-20250197359-A1 CANNABINOID RECEPTOR MODULATING COMPOUNDS THE U.S.A., AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2025-06-19 US disclosed
WO-2025040089-A1 NOVEL HETEROCYCLIC COMPOUND FOR SELECTIVELY REGULATING CANNABINOID CB1 FUNCTION 德睿智药(苏州)新药研发有限公司 2025-02-27 WO disclosed
US-20250049736-A1 SULFONAMIDE DERIVATIVES AND THEIR USE AS SOLUBLE EPOXIDE HYDROLASE INHIBITORS THE US SECRETARY DEPARTMENT OF HEALTH (US) 2025-02-13 US disclosed
EP-4504179-A1 CANNABINOID RECEPTOR 1 ANTAGONISTS/INVERSE AGONISTS AND USES THEREOF Corbus Pharmaceuticals, Inc. (US) 2025-02-12 EP disclosed
US-20250042861-A1 TETRAHYDROPYRIDAZINES, COMPOSITIONS COMPRISING THEM AND USES THEREOF NOVO NORDISK A/S (DK) 2025-02-06 US disclosed
EP-4493547-A1 CANNABINOID RECEPTOR MODULATING COMPOUNDS The United States of America, as represented by the Secretary, Department of Health and Human Services (US) 2025-01-22 EP disclosed
EP-3423448-B1 CANNABINOID RECEPTOR MEDIATING COMPOUNDS US HEALTH (US) 2024-12-04 EP disclosed
EP-4448491-A2 N-((ADAMANTAN-1-YL)CARBAMOYL)-BENZENESULFONAMIDE DERIVATIVES AS SOLUBLE EPOXIDE HYDROLASE INHIBITORS FOR THE TREATMENT OF HYPERTENSION The United States of America, as represented by the Secretary, Department of Health and Human Services (US) 2024-10-23 EP disclosed
EP-4448497-A1 TETRAHYDROPYRIDAZINES, COMPOSITIONS COMPRISING THEM AND USES THEREOF Novo Nordisk A/S (DK) 2024-10-23 EP disclosed
EP-1373216-B1 4,5-DIHYDRO-1H-PYRAZOLE DERIVATIVES HAVING CB1-ANTAGONISTIC ACTIVITY SOLVAY PHARM BV (NL) 2004-12-15 EP disclosed
US-20040248944-A1 Novel 4,5-dihydro-1h-pyrazole derivatives having cb1-antagonistic activity SOLVAY PHARMACEUTICALS B.V. (NL) 2004-12-09 US disclosed
EP-1429761-A1 NOVEL 4,5-DIHYDRO-1H-PYRAZOLE DERIVATIVES HAVING CB1-ANTAGONISTIC ACTIVITY Solvay Pharmaceuticals B.V. (NL) 2004-06-23 EP disclosed
EP-1373216-A1 4,5-DIHYDRO-1H-PYRAZOLE DERIVATIVES HAVING CB1-ANTAGONISTIC ACTIVITY Solvay Pharmaceuticals B.V. (NL) 2004-01-02 EP disclosed
WO-2003026647-A1 NOVEL 4,5-DIHYDRO-1H-PYRAZOLE DERIVATIVES HAVING CB1-ANTAGONISTIC ACTIVITY SOLVAY PHARMACEUTICALS B.V. (NL) 2003-04-03 WO disclosed
EP-1268435-A1 4,5-DIHYDRO-1H-PYRAZOLE DERIVATIVES HAVING CB 1-ANTAGONISTIC ACTIVITY Solvay Pharmaceuticals B.V. (NL) 2003-01-02 EP disclosed
US-6476060-B2 DRUG ABUSE; PSYCHOLOGICAL DISORDERS; GASTROINTESTINAL DISORDERS; CARDIOVASCUALR DISORDERS SOLVAY PHARMACEUTICALS, B.V. (NL) 2002-11-05 US disclosed
WO-2002076949-A1 4,5-DIHYDRO-1H-PYRAZOLE DERIVATIVES HAVING CB1-ANTAGONISTIC ACTIVITY SOLVAY PHARMACEUTICALS B.V. (NL) 2002-10-03 WO disclosed
US-20010053788-A1 4,5-dihydro-1H-pyrazole derivatives having CB1-antagonistic activity SOLVAY PHARMACEUTICALS B.V. 2001-12-20 US disclosed
WO-2001070700-A1 4,5-DIHYDRO-1H-PYRAZOLE DERIVATIVES HAVING CB1-ANTAGONISTIC ACTIVITY SOLVAY PHARMACEUTICALS B.V. (NL) 2001-09-27 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040248944-A1 Novel 4,5-dihydro-1h-pyrazole derivatives having cb1-antagonistic activity CNR1, CNR2, GPR55 FLT1 3404/4885FLT4 2932/4885KDR 2724/4885
US-20010053788-A1 4,5-dihydro-1H-pyrazole derivatives having CB1-antagonistic activity CNR1, CNR2, CBR3 FLT1 2175/4885FLT4 1875/4885KDR 2135/4885
US-20250248973-A1 CANNABINOID RECEPTOR 1 ANTAGONISTS/INVERSE AGONISTS AND USES THEREOF CNR1, CNR2, GPR119 FLT1 2150/4885FLT4 2365/4885KDR 1578/4885
US-20250049736-A1 SULFONAMIDE DERIVATIVES AND THEIR USE AS SOLUBLE EPOXIDE HYDROLASE INHIBITORS EPHX1, FAAH, ECE1 FLT1 794/4885FLT4 1180/4885KDR 1971/4885
US-20250042861-A1 TETRAHYDROPYRIDAZINES, COMPOSITIONS COMPRISING THEM AND USES THEREOF CNR1, CNR2, TAAR5 FLT1 2171/4885FLT4 3026/4885KDR 2123/4885
US-20250197359-A1 CANNABINOID RECEPTOR MODULATING COMPOUNDS CNR1, CNR2, GPR18 FLT1 1741/4885FLT4 1491/4885KDR 1289/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.