Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | FAAH | O00519 | 4/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3927266 | 0.81 | MCL1 (0.49) | KDM4EALOX15PKMALDH1A1GAA | |
| SCHEMBL3937537 | 0.80 | ALDH1A1 (0.49) | KDM4EALOX15PKMALDH1A1GAA | |
| SCHEMBL25244127 | 0.76 | SMN1; SMN2 (0.53) | KDM4EPKMALDH1A1FAAHMEN1 | |
| SCHEMBL3939039 | 0.73 | KDM4E (0.41) | KDM4EALOX15PKMALDH1A1GAA | |
| SCHEMBL3929765 | 0.73 | NPSR1 (0.46) | KDM4EALOX15PKMALDH1A1GAA | |
| SCHEMBL3929130 | 0.72 | TP53 (0.52) | KDM4EPKMALDH1A1GAASMN1; SMN2 | |
| SCHEMBL14367476 | 0.70 | VEGFA (0.45) | — | |
| SCHEMBL3930143 | 0.67 | PTGDR2 (0.65) | KDM4EALOX15PKMALDH1A1GAA | |
| SCHEMBL3932024 | 0.67 | VEGFA (0.51) | KDM4EALDH1A1GAAFAAHMEN1 | |
| SCHEMBL3928362 | 0.67 | CCR5 (0.55) | KDM4EALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044044-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2009-04-08 | — | — | EP | disclosed |
| WO-2007143745-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2007-12-13 | — | — | WO | disclosed |