Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 20/20 | 0.81 |
| ▸ | ADRB1 | P08588 | 20/20 | 0.81 |
| ▸ | ADRB3 | P13945 | 20/20 | 0.81 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.69 |
| ▸ | HTR1A | P08908 | 1/20 | 0.69 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.69 |
| ▸ | HTR1B | P28222 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4809676 | 1.00 | ADRB2 (0.81) | ADRB2ADRB1ADRB3CYP3A4HTR1A | |
| SCHEMBL4806575 | 1.00 | ADRB2 (0.81) | ADRB2ADRB1ADRB3CYP3A4HTR1A | |
| SCHEMBL4802387 | 1.00 | ADRB2 (0.81) | ADRB2ADRB1ADRB3CYP3A4HTR1A | |
| SCHEMBL4806819 | 1.00 | ADRB2 (0.81) | ADRB2ADRB1ADRB3CYP3A4HTR1A | |
| SCHEMBL4813365 | 1.00 | ADRB2 (0.81) | ADRB2ADRB1ADRB3CYP3A4HTR1A | |
| SCHEMBL4808818 | 0.98 | ADRB2 (0.79) | ADRB2ADRB1ADRB3CYP3A4HTR1A | |
| SCHEMBL4810624 | 0.98 | ADRB2 (0.79) | ADRB2ADRB1ADRB3CYP3A4HTR1A | |
| SCHEMBL926097 | 0.94 | ADRB2 (0.82) | ADRB2ADRB1ADRB3 | |
| SCHEMBL4809560 | 0.94 | ADRB2 (0.72) | ADRB2ADRB1ADRB3CYP3A4HTR1A | |
| SCHEMBL4801202 | 0.92 | ADRB2 (0.82) | ADRB2ADRB1ADRB3CYP3A4HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2039700-A2 | Novel anti-inflammatory androstane derivatives | Glaxo Group Limited (GB) | 2009-03-25 | — | — | EP | disclosed |
| US-7442719-B2 | Methods using phenethanolamine derivatives for treatment of respiratory diseases | GLAXO GROUP LIMITED (GB) | 2008-10-28 | — | — | US | disclosed |
| US-7442837-B2 | Phenethanolamine derivatives for treatment of respiratory diseases | GLAXO GROUP LIMITED (GB) | 2008-10-28 | — | — | US | disclosed |
| US-7442836-B2 | Prophylaxis of respiratory disorders and therapy, also metod of synthesis and composition with PDE4 inhibitor, corticosteroid hibitor or anticholinergic agent | GLAXO GROUP LIMITED (GB) | 2008-10-28 | — | — | US | disclosed |
| EP-1383786-B1 | ANTI-INFLAMMATORY 17.BETA.-CARBOTHIOATE ESTER DERIVATIVES OF ANDROSTANE WITH A CYCLIC ESTER GROUP IN POSITION 17.ALPHA | GLAXO GROUP LTD (GB) | 2008-10-15 | — | — | EP | disclosed |
| US-7405206-B2 | Anti-inflammatory androstane derivatives | GLAXO GROUP LIMITED (GB) | 2008-07-29 | — | — | US | disclosed |
| EP-1395604-B1 | NOVEL ANTI INFLAMMATORY 17.ALPHA.-HETEROCYCLIC-ESTERS OF 17.BETA.-CARBOTHIOATE ANDROSTANE DERIVATIVES | GLAXO GROUP LTD (GB) | 2008-06-25 | — | — | EP | disclosed |
| EP-1444248-B1 | NOVEL ANTI-INFLAMMATORY ANDROSTANE DERIVATIVES - 17-CARBOXY-LACTONE SUBSTITUTED STEROIDS WITH AN ARYL-CARBOXYLIC ESTER IN POSITION 17.ALPHA | GLAXO GROUP LTD (GB) | 2008-04-30 | — | — | EP | disclosed |
| US-20070297989-A1 | NOVEL ANTI-INFLAMMATORY ANDROSTANE DERIVATIVES | BIGGADIKE KEITH | 2007-12-27 | — | — | US | disclosed |
| US-7291608-B2 | Anti-inflammatory 17.β.-carbothioate ester derivatives of androstane with a cyclic ester group in position 17.α | GLAXO GROUP LIMITED (US) | 2007-11-06 | — | — | US | disclosed |
| US-20070004807-A1 | e.g. 2-[9-chloro-6-(3-hydroxy-3-methylbutyl-1-yn-1-yl)-1H-phenanthro[9,10-d]imidazol-2-yl]-3-fluorobenzonitrile; microsomal prostaglandin E synthase inhibitor; analgesic, antiinflammatory agent; osteoarthritis, rheumatoid arthritis and acute or chronic pain; side effect reducer | GLAXO GROUP LIMITED (GB) | 2007-01-04 | — | — | US | disclosed |
| US-20060287389-A1 | PHENETHANOLAMINE DERIVATIVES FOR TREATMENT OF RESPIRATORY DISEASES | GLAXO GROUP LIMITED (GB) | 2006-12-21 | — | — | US | disclosed |
| US-20060287286-A1 | PHENETHANOLAMINE DERIVATIVES FOR TREATMENT OF RESPIRATORY DISEASES | GLAXO GROUP LIMITED (GB) | 2006-12-21 | — | — | US | disclosed |
| US-7135600-B2 | Selective beta 2-adrenoreceptor agonists; rapid onset of action, long duration; such as 3-(4-{[6-{(-2-hydroxy-2-[4-hydroxy-3-(hydroxymethyl)phenyl]ethyl}amino)hexyl]oxy}butyl)benzenesulfonamide; synthesis | GLAXO GROUP LIMITED (GB) | 2006-11-14 | — | — | US | disclosed |
| US-20050054622-A1 | Novel anti-inflammatory androstane derivatives | GLAXO GROUP LIMITED (GB) | 2005-03-10 | — | — | US | disclosed |
| US-20040248867-A1 | Novel anti-inflammatory 17.alpha.-heterocyclic-esters of 17.beta.carbothioate androstane derivatives | GLAXO GROUP LIMITED (GB) | 2004-12-09 | — | — | US | disclosed |
| US-20040180876-A1 | Phenethanolamine derivatives for treatment of respiratory diseases | GLAXO GROUP LIMITED (GB) | 2004-09-16 | — | — | US | disclosed |
| US-20040171597-A1 | Anti-inflammatory 17.beta.-carbothioate ester derivatives of androstane with a cyclic ester group in position 17.alpha | GLAXO GROUP LIMITED (GB) | 2004-09-02 | — | — | US | disclosed |
| US-20040072819-A1 | Benzoxazepine compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES, LTD. | 2004-04-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060287389-A1 | PHENETHANOLAMINE DERIVATIVES FOR TREATMENT OF RESPIRATORY DISEASES | PHOSPHO1, PNMT, PEBP1 | ADRB2 89/4885ADRB1 192/4885ADRB3 128/4885 |
| US-20040171597-A1 | Anti-inflammatory 17.beta.-carbothioate ester derivatives of androstane with a cyclic ester group in position 17.alpha | NR5A1, HSD17B7, HSD17B1 | ADRB2 148/4885ADRB1 87/4885ADRB3 127/4885 |
| US-20040248867-A1 | Novel anti-inflammatory 17.alpha.-heterocyclic-esters of 17.beta.carbothioate androstane derivatives | HSD17B1, NR5A1, HSD17B7 | ADRB2 165/4885ADRB1 85/4885ADRB3 133/4885 |
| US-20040072819-A1 | Benzoxazepine compounds, their production and use | CES1, CETP, CYP46A1 | ADRB2 595/4885ADRB1 310/4885ADRB3 746/4885 |
| US-20060287286-A1 | PHENETHANOLAMINE DERIVATIVES FOR TREATMENT OF RESPIRATORY DISEASES | PHOSPHO1, PNMT, PEBP1 | ADRB2 89/4885ADRB1 192/4885ADRB3 128/4885 |
| US-20070297989-A1 | NOVEL ANTI-INFLAMMATORY ANDROSTANE DERIVATIVES | NR5A1, HSD3B2, HSD3B1 | ADRB2 80/4885ADRB1 64/4885ADRB3 79/4885 |
| US-20040180876-A1 | Phenethanolamine derivatives for treatment of respiratory diseases | PHOSPHO1, PNMT, PEBP1 | ADRB2 89/4885ADRB1 192/4885ADRB3 128/4885 |
| US-20050054622-A1 | Novel anti-inflammatory androstane derivatives | NR5A1, HSD3B2, HSD3B1 | ADRB2 59/4885ADRB1 42/4885ADRB3 65/4885 |
| US-20070004807-A1 | e.g. 2-[9-chloro-6-(3-hydroxy-3-methylbutyl-1-yn-1-yl)-1H-phenanthro[9,10-d]imidazol-2-yl]-3-fluorobenzonitrile; microsomal prostaglandin E synthase inhibitor; analgesic, antiinflammatory agent; osteoarthritis, rheumatoid arthritis and acute or chronic pain; side effect reducer | PTGS1, PTGES, PTGES2 | ADRB2 701/4885ADRB1 369/4885ADRB3 831/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.