Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FKBP1A | P62942 | 4/20 | 0.45 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.39 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3930700 | 0.80 | TRPA1 (0.46) | FKBP1APTGDR2TSHRALDH1A1 | |
| SCHEMBL3941700 | 0.76 | BCL9 (0.54) | PTGDR2ALDH1A1SMN1; SMN2CYP2C19 | |
| SCHEMBL3928274 | 0.74 | TRPA1 (0.57) | FKBP1ATSHRALDH1A1SMN1; SMN2CYP3A4 | |
| SCHEMBL3932070 | 0.71 | ALDH1A1 (0.50) | PTGDR2TSHRALDH1A1SMN1; SMN2PKM | |
| SCHEMBL3931870 | 0.70 | PTGDR2 (0.49) | PTGDR2TSHRALDH1A1PKMCYP3A4 | |
| SCHEMBL13570535 | 0.69 | FKBP1A (0.62) | FKBP1ATSHRALDH1A1MMP2MMP9 | |
| SCHEMBL13570536 | 0.69 | FKBP1A (0.62) | FKBP1ATSHRALDH1A1MMP2MMP9 | |
| SCHEMBL3933560 | 0.69 | THRB (0.44) | TSHRALDH1A1SMN1; SMN2HCRTR1HCRTR2 | |
| SCHEMBL3929084 | 0.69 | MAPT (0.55) | PTGDR2TSHRALDH1A1SMN1; SMN2HCRTR1 | |
| SCHEMBL3941517 | 0.69 | MAPT (0.55) | PTGDR2TSHRALDH1A1SMN1; SMN2HCRTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044017-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2009-04-08 | — | — | EP | disclosed |
| WO-2007146838-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2007-12-21 | — | — | WO | disclosed |