Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 6/20 | 0.45 |
| ▸ | DRD2 | P14416 | 5/20 | 0.45 |
| ▸ | ELOVL6 | Q9H5J4 | 1/20 | 0.44 |
| ▸ | DRD1 | P21728 | 1/20 | 0.43 |
| ▸ | DRD4 | P21917 | 1/20 | 0.43 |
| ▸ | DRD5 | P21918 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3933831 | 0.89 | DRD3 (0.47) | DRD3DRD2ELOVL6DRD1DRD4 | |
| SCHEMBL3936397 | 0.89 | DRD2 (0.45) | DRD3DRD2DRD1DRD4DRD5 | |
| SCHEMBL3930618 | 0.86 | ALDH1A1 (0.53) | TSHRPOLBALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL3943769 | 0.86 | DRD2 (0.45) | DRD3DRD2DRD1DRD4DRD5 | |
| SCHEMBL27768400 | 0.83 | DRD3 (0.41) | DRD3DRD2DRD1DRD4DRD5 | |
| SCHEMBL3941453 | 0.83 | BCL9 (0.47) | DRD3DRD2ALDH1A1NPC1HTT | |
| Ethylbenzene SCHEMBL27747313 | 0.82 | ALDH1A1 (0.40) | DRD3DRD2DRD1DRD4DRD5 | |
| SCHEMBL3936472 | 0.82 | TP53 (0.48) | ALDH1A1NPC1HTT | |
| SCHEMBL3940272 | 0.81 | ALDH1A1 (0.50) | DRD3DRD2DRD1DRD4DRD5 | |
| 1,2-Dichlorobenzene SCHEMBL27747023 | 0.80 | ALDH1A1 (0.38) | DRD3DRD2DRD1DRD4DRD5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044017-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2009-04-08 | — | — | EP | disclosed |
| WO-2007146838-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2007-12-21 | — | — | WO | disclosed |