Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CES1 | P23141 | 6/20 | 0.37 |
| ▸ | CES2 | O00748 | 5/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.34 |
| ▸ | FABP3 | P05413 | 5/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL8382075 | 0.98 | CA1 (0.39) | CA1CES1CES2ATMBBOX1 | |
| Fumaric Acid SCHEMBL621871 | 0.98 | CA1 (0.39) | CA1CES1CES2ATMBBOX1 | |
| Fumaric Acid SCHEMBL48774 | 0.98 | CA1 (0.39) | CA1CES1CES2ATMBBOX1 | |
| Fumaric Acid SCHEMBL3685229 | 0.98 | CA1 (0.39) | CA1CES1CES2ATMBBOX1 | |
| Fumaric Acid SCHEMBL8378110 | 0.98 | CA1 (0.39) | CA1CES1CES2ATMBBOX1 | |
| Fumaric Acid SCHEMBL48771 | 0.98 | CA1 (0.39) | CA1CES1CES2ATMBBOX1 | |
| Fumaric Acid SCHEMBL28546317 | 0.96 | CA1 (0.38) | CA1CES1CES2ATMBBOX1 | |
| Fumaric Acid SCHEMBL3629101 | 0.96 | CA1 (0.38) | CA1CES1CES2ATMBBOX1 | |
| Fumaric Acid SCHEMBL28649556 | 0.92 | CES2 (0.41) | CES1CES2FABP3 | |
| Fumaric Acid SCHEMBL28841512 | 0.92 | CA1 (0.35) | CA1CES1CES2ATMBBOX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025075042-A1 | TWO-PACK TYPE CURABLE COMPOSITION AND USE THEREOF | 株式会社カネカ | 2025-04-10 | — | — | WO | disclosed |
| US-8642669-B2 | Foamable low-viscosity mixtures | HENKEL AG & CO., KGAA (DE) | 2014-02-04 | — | — | US | disclosed |
| US-20120260934-A1 | HAIR TREATMENT AGENTS COMPRISING TRIALKOXYSILANE-SUBSTITUTED COMPOUNDS AND ALKOXYSILYL-MODIFIED MACRO MOLECULES | SCHWEINSBERG MATTHIAS (DE) | 2012-10-18 | — | — | US | disclosed |
| US-8101681-B2 | Prepolymer mixture containing silyl groups and use thereof | HENKEL AG & CO. KGAA (DE) | 2012-01-24 | — | — | US | disclosed |
| EP-1586605-B1 | POLYMER AND CURABLE COMPOSITIONS IMPROVED IN STORAGE STABILITY | KANEKA CORP (JP) | 2011-11-02 | — | — | EP | disclosed |
| US-20110224319-A1 | FOAMABLE LOW-VISCOSITY MIXTURES | HENKEL AG & CO. KGAA (DE) | 2011-09-15 | — | — | US | disclosed |
| US-7977399-B2 | Curable composition | KANEKA CORPORATION (JP) | 2011-07-12 | — | — | US | disclosed |
| US-7820749-B2 | Curable resin composition | KANEKA CORPORATION (JP) | 2010-10-26 | — | — | US | disclosed |
| EP-2072577-B1 | CURABLE COMPOSITION | KANEKA CORP (JP) | 2010-08-04 | — | — | EP | disclosed |
| US-20100105798-A1 | CURABLE COMPOSITION | KANEKA CORPORATION (JP) | 2010-04-29 | — | — | US | disclosed |
| US-20090306283-A1 | PREPOLYMER MIXTURE CONTAINING SILYL GROUPS AND USE THEREOF | HENKEL AG & CO. KGAA (DE) | 2009-12-10 | — | — | US | disclosed |
| US-20090170995-A1 | Curable Resin Composition | KANEKA CORPORATION (JP) | 2009-07-02 | — | — | US | disclosed |
| EP-2072577-A1 | CURABLE COMPOSITION | Kaneka Corporation (JP) | 2009-06-24 | — | — | EP | disclosed |
| EP-2011833-A1 | CURABLE RESIN COMPOSITION | Kaneka Corporation (JP) | 2009-01-07 | — | — | EP | disclosed |
| US-20070161768-A1 | Method for producing hydrolyzable silicon group-containing oxyalkylene polymer and curing composition thereof | KANEKA CORPORATION (JP) | 2007-07-12 | — | — | US | disclosed |
| EP-1710270-A1 | METHOD FOR PRODUCING HYDROLYZABLE SILICON GROUP-CONTAINING OXYALKYLENE POLYMER AND CURING COMPOSITION THEREOF | Kaneka Medix Corporation (JP) | 2006-10-11 | — | — | EP | disclosed |
| US-20060205887-A1 | Polymer and curable compositions improved in storage stability | KANEKA CORPORATION (JP) | 2006-09-14 | — | — | US | disclosed |
| US-20060173121-A1 | Curable composition | KANEKA CORPORATION (JP) | 2006-08-03 | — | — | US | disclosed |
| EP-1650261-A1 | CURABLE COMPOSITION | KANEKA CORPORATION (JP) | 2006-04-26 | — | — | EP | disclosed |
| EP-1586605-A1 | POLYMER AND CURABLE COMPOSITIONS IMPROVED IN STORAGE STABILITY | KANEKA CORPORATION (JP) | 2005-10-19 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120260934-A1 | HAIR TREATMENT AGENTS COMPRISING TRIALKOXYSILANE-SUBSTITUTED COMPOUNDS AND ALKOXYSILYL-MODIFIED MACRO MOLECULES | KRT18, MARK1, TLN1 | CA1 3561/4885CES1 3492/4885CES2 3870/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.