Fumaric Acid

Fumaric Acid

SCHEMBL3685229

CCCC[Sn+2]CCCC.CCCC[Sn+2]CCCC.O=C([O-])C=CC(=O)[O-].O=C([O-])C=CC(=O)[O-]

nearest known ligand 0.46

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol

The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
CA1 P00915 2/20 0.39
CES1 P23141 6/20 0.39
CES2 O00748 5/20 0.39
ATM Q13315 1/20 0.35
BBOX1 O75936 1/20 0.35
FABP3 P05413 5/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Fumaric Acid SCHEMBL48771 1.00 CA1 (0.39) CA1CES1CES2ATMBBOX1
Fumaric Acid SCHEMBL48774 1.00 CA1 (0.39) CA1CES1CES2ATMBBOX1
Fumaric Acid SCHEMBL621871 1.00 CA1 (0.39) CA1CES1CES2ATMBBOX1
Fumaric Acid SCHEMBL8382075 1.00 CA1 (0.39) CA1CES1CES2ATMBBOX1
Fumaric Acid SCHEMBL8378110 1.00 CA1 (0.39) CA1CES1CES2ATMBBOX1
Fumaric Acid SCHEMBL3629101 0.98 CA1 (0.38) CA1CES1CES2ATMBBOX1
Fumaric Acid SCHEMBL394440 0.98 CA1 (0.38) CA1CES1CES2ATMBBOX1
Fumaric Acid SCHEMBL28546317 0.98 CA1 (0.38) CA1CES1CES2ATMBBOX1
Fumaric Acid SCHEMBL28841512 0.94 CA1 (0.35) CA1CES1CES2ATMBBOX1
Fumaric Acid SCHEMBL28649556 0.94 CES2 (0.41) CES1CES2FABP3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7718749-B2 Curable composition KANEKA CORPORATION (JP) 2010-05-18 US claimed
JP-3803880-B2 2006-08-02 JP claimed
EP-0783543-A4 MOLDABLE THERMOPLASTIC POLYMER FOAM BEADS KNAUS DENNIS A (US) 1998-11-11 EP claimed
EP-0783543-A1 MOLDABLE THERMOPLASTIC POLYMER FOAM BEADS Knaus, Dennis A. (US) 1997-07-16 EP claimed
WO-1996010600-A1 MOLDABLE THERMOPLASTIC POLYMER FOAM BEADS KNAUS DENNIS A (US) 1996-04-11 WO claimed
US-20220403586-A1 METHODS OF USING A PHENOLIC FATTY ACID COMPOUND ON A SYNTHETIC FABRIC MATERIAL SI GROUP, INC. 2022-12-22 US disclosed
US-11390987-B2 Methods of using a phenolic fatty acid compound on a synthetic fabric material SI GROUP, INC. (US) 2022-07-19 US disclosed
EP-3635063-A1 FIRE PROTECTION COMPOSITION, MULTI-COMPONENT SYSTEM AND USE THEREOF Hilti Aktiengesellschaft (LI) 2020-04-15 EP disclosed
EP-3116940-B1 METHODS OF USING A PHENOLIC FATTY ACID COMPOUND ON A NON-PHENOLIC POLYMER SI GROUP INC (US) 2020-02-26 EP disclosed
US-10030332-B2 Methods of using phenolic fatty acid compound on a non-phenolic polymer SI GROUP, INC. (US) 2018-07-24 US disclosed
US-20170204559-A1 METHODS OF USING PHENOLIC FATTY ACID COMPOUND ON A NON-PHENOLIC POLYMER SI GROUP, INC. (US) 2017-07-20 US disclosed
US-20170073884-A1 METHODS OF USING A PHENOLIC FATTY ACID COMPOUND ON A SYNTHETIC FABRIC MATERIAL SI GROUP, INC. 2017-03-16 US disclosed
EP-3116939-A2 METHODS OF USING A PHENOLIC FATTY ACID COMPOUND ON A SYNTHETIC FABRIC MATERIAL SI Group, Inc. (US) 2017-01-18 EP disclosed
EP-3116940-A2 METHODS OF USING A PHENOLIC FATTY ACID COMPOUND ON A NON-PHENOLIC POLYMER SI Group, Inc. (US) 2017-01-18 EP disclosed
WO-2015138955-A2 METHODS OF USING A PHENOLIC FATTY ACID COMPOUND ON A SYNTHETIC FABRIC MATERIAL SI GROUP, INC. (US) 2015-09-17 WO disclosed
US-5981652-A COMPRISING RESIN COMPONENTS WHICH INCLUDE A POLYESTERPOLYOL WITH A ACRYLIC POLYOL, A CROSSLINKING AGENT, WHICH INCLUDES A BLOCKED ISOCYANATE AND MAY FURTHER INCLUDE A MELAMINE RESIN, A BLOCKED ISOCYANATE DISSOCIATION CATALYST; CAR BUMPER COATINGS TOYOTA JIDOSHA KABUSHIKI KAISHA (JP) 1999-11-09 US disclosed
EP-0406349-A4 IMPROVED STABILIZERS FOR HALOGEN-CONTAINING POLYMERS 1991-03-20 EP disclosed
EP-0406349-A1 IMPROVED STABILIZERS FOR HALOGEN-CONTAINING POLYMERS. M & T CHEMICALS INC (US) 1991-01-09 EP disclosed
EP-0365289-A2 Method for producing a filled water-crosslinkable silane copolymer composition NESTE OY (FI) 1990-04-25 EP disclosed
WO-1990003999-A1 IMPROVED STABILIZERS FOR HALOGEN-CONTAINING POLYMERS M&T CHEMICALS INC. (US) 1990-04-19 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170204559-A1 METHODS OF USING PHENOLIC FATTY ACID COMPOUND ON A NON-PHENOLIC POLYMER FABP4, FASN, ALOX5 CA1 4342/4885CES1 1020/4885CES2 669/4885
US-10030332-B2 Methods of using phenolic fatty acid compound on a non-phenolic polymer FABP4, FASN, ALOX5 CA1 4342/4885CES1 1020/4885CES2 669/4885
US-20220403586-A1 METHODS OF USING A PHENOLIC FATTY ACID COMPOUND ON A SYNTHETIC FABRIC MATERIAL FASN, FABP4, ALOX5 CA1 4149/4885CES1 1094/4885CES2 585/4885
US-11390987-B2 Methods of using a phenolic fatty acid compound on a synthetic fabric material FASN, FABP4, ALOX5 CA1 4149/4885CES1 1094/4885CES2 585/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.