Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | CES1 | P23141 | 6/20 | 0.39 |
| ▸ | CES2 | O00748 | 5/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.35 |
| ▸ | FABP3 | P05413 | 5/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL48771 | 1.00 | CA1 (0.39) | CA1CES1CES2ATMBBOX1 | |
| Fumaric Acid SCHEMBL3685229 | 1.00 | CA1 (0.39) | CA1CES1CES2ATMBBOX1 | |
| Fumaric Acid SCHEMBL48774 | 1.00 | CA1 (0.39) | CA1CES1CES2ATMBBOX1 | |
| Fumaric Acid SCHEMBL8382075 | 1.00 | CA1 (0.39) | CA1CES1CES2ATMBBOX1 | |
| Fumaric Acid SCHEMBL8378110 | 1.00 | CA1 (0.39) | CA1CES1CES2ATMBBOX1 | |
| Fumaric Acid SCHEMBL3629101 | 0.98 | CA1 (0.38) | CA1CES1CES2ATMBBOX1 | |
| Fumaric Acid SCHEMBL394440 | 0.98 | CA1 (0.38) | CA1CES1CES2ATMBBOX1 | |
| Fumaric Acid SCHEMBL28546317 | 0.98 | CA1 (0.38) | CA1CES1CES2ATMBBOX1 | |
| Fumaric Acid SCHEMBL28841512 | 0.94 | CA1 (0.35) | CA1CES1CES2ATMBBOX1 | |
| Fumaric Acid SCHEMBL28649556 | 0.94 | CES2 (0.41) | CES1CES2FABP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 58 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118591450-A | Polymer composition with densification promoter and rotational molding method for manufacturing hollow article therefrom | 塞特工业公司 | 2024-09-03 | — | — | CN | claimed |
| US-4973737-A | ORGANOTIN OR ORGANOTITANATE CATALYST, BY-PRODUCT INHIBITION | KABUSHIKI KAISHA VENO SEIYAKU OYO KENKYUO (JP) | 1990-11-27 | — | — | US | claimed |
| CN-120157790-A | Preparation method of polyvinyl chloride | 浙江镇洋发展股份有限公司 | 2025-06-17 | — | — | CN | disclosed |
| CN-119894997-A | Colored free radical curable inkjet inks | 爱克发有限公司 | 2025-04-25 | — | — | CN | disclosed |
| CN-119744288-A | Curable inkjet composition for manufacturing printed circuit boards | 爱克发-格法特公司 | 2025-04-01 | — | — | CN | disclosed |
| CN-119562997-A | Curable inkjet composition for manufacturing printed circuit boards | 爱克发-格法特公司 | 2025-03-04 | — | — | CN | disclosed |
| CN-119562996-A | Curable inkjet composition for manufacturing printed circuit boards | 爱克发-格法特公司 | 2025-03-04 | — | — | CN | disclosed |
| CN-119343414-A | Inkjet printing method | 爱克发有限公司 | 2025-01-21 | — | — | CN | disclosed |
| CN-116940642-B | Method for manufacturing decorative surface | 爱克发有限公司 | 2024-12-17 | — | — | CN | disclosed |
| CN-114746501-B | Halogen-free flame retardant polymer composition | 陶氏环球技术有限责任公司 | 2024-12-06 | — | — | CN | disclosed |
| CN-116390929-B | UV curable inkjet inks and inkjet printing methods | 爱克发有限公司 | 2024-11-26 | — | — | CN | disclosed |
| WO-2012020027-A1 | LIGHT-FAST POLYURETHANES AND USE THEREOF | BAYER MATERIALSCIENCE AG (DE) | 2012-02-16 | — | — | WO | disclosed |
| EP-1195397-B1 | Composition of cyclic olefin addition copolymer and cross-linked material | JSR CORP (JP) | 2004-04-14 | — | — | EP | disclosed |
| US-20020042461-A1 | Composition of cyclic olefin addition copolymer and cross-linked material | JSR CORPORATION (JP) | 2002-04-11 | — | — | US | disclosed |
| EP-1195397-A1 | Composition of cyclic olefin addition copolymer and cross-linked material | JSR Corporation (JP) | 2002-04-10 | — | — | EP | disclosed |
| US-4973737-A | ORGANOTIN OR ORGANOTITANATE CATALYST, BY-PRODUCT INHIBITION | KABUSHIKI KAISHA VENO SEIYAKU OYO KENKYUO (JP) | 1990-11-27 | — | — | US | disclosed |
| US-4935275-A | STABILIZERS TO IMPROVE WEATHERABILITY AND COLORFASTNESS | TOYODA GOSEI CO., LTD. (JP) | 1990-06-19 | — | — | US | disclosed |
| EP-0117502-B1 | PROCESS FOR PRODUCING BENZYL ESTERS OF AROMATIC HYDROXYCARBOXYLIC ACIDS | Kabushiki Kaisha Ueno Seiyaku Oyo Kenkyujo (JP) | 1987-11-19 | — | — | EP | disclosed |
| US-4582661-A | MOLDING MATERIALS, COPPER METAL OR ALLOY EMBEDDED IN VINYL CHLORIDE RESIN AND ACRYLONITRILE-BUTADIENE-STYRENE TERPOLYMER | DAINICHI-NIPPON CABLES, LTD. (JP) | 1986-04-15 | — | — | US | disclosed |
| EP-0113785-A1 | COMPOSITION FOR SHIELDING ELECTROMAGNETIC WAVES | Mitsubishi Cable Industries, Ltd. (JP) | 1984-07-25 | — | — | EP | disclosed |