Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | CES1 | P23141 | 6/20 | 0.39 |
| ▸ | CES2 | O00748 | 5/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.35 |
| ▸ | FABP3 | P05413 | 5/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL48771 | 1.00 | CA1 (0.39) | CA1CES1CES2ATMBBOX1 | |
| Fumaric Acid SCHEMBL3685229 | 1.00 | CA1 (0.39) | CA1CES1CES2ATMBBOX1 | |
| Fumaric Acid SCHEMBL621871 | 1.00 | CA1 (0.39) | CA1CES1CES2ATMBBOX1 | |
| Fumaric Acid SCHEMBL8382075 | 1.00 | CA1 (0.39) | CA1CES1CES2ATMBBOX1 | |
| Fumaric Acid SCHEMBL8378110 | 1.00 | CA1 (0.39) | CA1CES1CES2ATMBBOX1 | |
| Fumaric Acid SCHEMBL3629101 | 0.98 | CA1 (0.38) | CA1CES1CES2ATMBBOX1 | |
| Fumaric Acid SCHEMBL394440 | 0.98 | CA1 (0.38) | CA1CES1CES2ATMBBOX1 | |
| Fumaric Acid SCHEMBL28546317 | 0.98 | CA1 (0.38) | CA1CES1CES2ATMBBOX1 | |
| Fumaric Acid SCHEMBL28841512 | 0.94 | CA1 (0.35) | CA1CES1CES2ATMBBOX1 | |
| Fumaric Acid SCHEMBL28649556 | 0.94 | CES2 (0.41) | CES1CES2FABP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 12146 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3956368-B1 | LATENT CATALYST | DOW GLOBAL TECHNOLOGIES LLC (US) | 2026-05-27 | — | — | EP | claimed |
| CN-122060237-A | Silane self-crosslinking polyethylene pipe with antibacterial property and preparation method thereof | 日丰企业（佛山）有限公司 | 2026-05-19 | — | — | CN | claimed |
| CN-119592294-B | Quick-curing bi-component condensation dealcoholized silicone adhesive and preparation method thereof | 万华化学集团股份有限公司 | 2026-05-19 | — | — | CN | claimed |
| CN-122037116-A | Combined polyether, polyurethane composition, polyurethane foam, preparation method of polyurethane foam and refrigeration equipment | TCL家用电器（合肥）有限公司 | 2026-05-15 | — | — | CN | claimed |
| CN-122037135-A | Composition, polyurethane foam material, preparation method of polyurethane foam material and refrigeration equipment | TCL家用电器（合肥）有限公司 | 2026-05-15 | — | — | CN | claimed |
| EP-4530311-B1 | MICROCELLULAR FOAMED AND THERMALLY INSULATED DOOR SEALING MATERIAL AND PREPARATION METHOD THEREOF | QINGDAO JIESHENG NEW MATERIAL TECH CO LTD (CN) | 2026-04-08 | — | — | EP | claimed |
| CN-121574564-A | Liquid silicone rubber for cold-shrink cable accessories and preparation method thereof | 东莞市正安有机硅科技有限公司 | 2026-02-27 | — | — | CN | claimed |
| CN-121572687-A | Layered flame-retardant polyurethane composite material and preparation method thereof | 深圳市力信陆南实业有限公司 | 2026-02-27 | — | — | CN | claimed |
| US-20260015521-A1 | THERMOSETTING COATING COMPOSITION WITH IMPROVED SCRATCH RESISTANCE | EASTMAN CHEMICAL COMPANY (US) | 2026-01-15 | — | — | US | claimed |
| EP-4665792-A1 | FILLED MOISTURE-CROSSLINKABLE POLYMERIC COMPOSITIONS | Dow Global Technologies LLC (US) | 2025-12-24 | — | — | EP | claimed |
| US-4147636-A | FOR POLYPROPYLENE | SANDOZ LTD. (CH) | 1979-04-03 | — | — | US | claimed |
| EP-0000792-A1 | X-ray image intensifying screens | AGFA-GEVAERT N.V. (BE) | 1979-02-21 | — | — | EP | claimed |
| US-4138361-A | IMAGE INTENSIFIER; HALIDE-CONTAINING PHOSPHOR, ORGANO-METALLIC SUBSTANCE AS STABILIZER | AGFA-GEVAERT N.V. (BE) | 1979-02-06 | — | — | US | claimed |
| US-4137211-A | FIREPROOFING | INTERNATIONAL BUSINESS MACHINES CORPORATION (US) | 1979-01-30 | — | — | US | claimed |
| US-4113672-A | Molding expandable styrene polymer particles | ARCO POLYMERS, INC. (US) | 1978-09-12 | — | — | US | claimed |
| US-4089912-A | DIALKYLTIN MALEATE, PHENOLIC ANTIOXIDANT; ESTERS, IMIDES, OR ANHYDRIDES OF CYCLIC DICARBOXYLIC ACIDS, OR POLYMERIC ESTERS | GREAT LAKES CHEMICAL CORPORATION (US) | 1978-05-16 | — | — | US | claimed |
| US-4061844-A | AMINOALKYL ACRYLATE COPOLYMER, SILICON OR TIN COMPOUND | SUMITOMO CHEMICAL COMPANY, LIMITED (JA) | 1977-12-06 | — | — | US | claimed |
| US-4052350-A | CALCIUM COMPOUND | SEKISUI KAGAKU KOGYO KABUSHIKI KAISHA (JA) | 1977-10-04 | — | — | US | claimed |
| US-4002809-A | Method of manufacturing acrylic fibers | KANEGAFUCHI KAGAKU KOGYO KABUSHIKI KAISHA (JA) | 1977-01-11 | — | — | US | claimed |
| US-3962155-A | MOLDED FOAMS AND PROCESS FOR PRODUCING THE SAME | SUMITOMO CHEMICAL COMPANY, LIMITED (JA) | 1976-06-08 | — | — | US | claimed |