Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRSS1 | P07477 | 5/20 | 0.61 |
| ▸ | PRSS3 | P35030 | 5/20 | 0.61 |
| ▸ | PRSS2 | P07478 | 4/20 | 0.61 |
| ▸ | F10 | P00742 | 1/20 | 0.61 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.61 |
| ▸ | WDR5 | P61964 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | TOP1 | P11387 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | NQO2 | P16083 | 1/20 | 0.52 |
| ▸ | CASP1 | P29466 | 1/20 | 0.52 |
| ▸ | CASP7 | P55210 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | F2 | P00734 | 4/20 | 0.52 |
| ▸ | TMPRSS6 | Q8IU80 | 1/20 | 0.52 |
| ▸ | ST14 | Q9Y5Y6 | 1/20 | 0.52 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.52 |
| ▸ | PLG | P00747 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2717268 | 0.93 | PRSS1 (0.70) | PRSS1PRSS3PRSS2F10LOXL2 | |
| SCHEMBL394218 | 0.85 | WDR5 (0.80) | PRSS1PRSS3PRSS2F10LOXL2 | |
| SCHEMBL8973288 | 0.85 | WDR5 (0.80) | PRSS1PRSS3PRSS2F10LOXL2 | |
| SCHEMBL27680541 | 0.84 | PRSS1 (0.69) | PRSS1PRSS3PRSS2F10LOXL2 | |
| Hydrochloric Acid SCHEMBL28584052 | 0.83 | PRSS1 (0.67) | PRSS1PRSS3PRSS2F10LOXL2 | |
| SCHEMBL31490985 | 0.83 | PRSS1 (0.57) | PRSS1PRSS3PRSS2F10LOXL2 | |
| SCHEMBL397362 | 0.80 | CYP11B1 (0.50) | PRSS1PRSS3PRSS2F10LOXL2 | |
| SCHEMBL21295028 | 0.78 | PRSS1 (0.52) | PRSS1PRSS3PRSS2F10LOXL2 | |
| SCHEMBL10092625 | 0.77 | CYP17A1 (0.52) | PRSS1PRSS3PRSS2F10LOXL2 | |
| SCHEMBL537030 | 0.77 | LMNA (0.77) | PRSS1PRSS3PRSS2F10LOXL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060293328-A1 | Linear dicationic terphenyls and their aza analogues as antiparasitic agents | TIDWELL RICHARD R | 2006-12-28 | — | — | US | claimed |
| EP-1736466-A1 | Linear dicationic terphenyls and their aza analogues as antiparasitic agents | The University of North Carolina at Chapel Hill (US) | 2006-12-27 | — | — | EP | claimed |
| US-8188121-B2 | Substituted pyridines as antiparasitic AZA teraryl compounds | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2012-05-29 | — | — | US | disclosed |
| US-8101636-B2 | Linear dicationic terphenyls and their aza analogues as antiparasitic agents | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2012-01-24 | — | — | US | disclosed |
| US-20110257199-A1 | NOVEL TERARYL COMPOUNDS AS ANTIPARASITIC AGENTS | TIDWELL RICHARD R | 2011-10-20 | — | — | US | disclosed |
| US-7964619-B2 | Teraryl components as antiparasitic agents | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2011-06-21 | — | — | US | disclosed |
| EP-1949896-A2 | Linear dicationic terphenyls and their aza analogues as antiparasitic agents | The University of North Carolina At Chapel Hill (US) | 2008-07-30 | — | — | EP | disclosed |
| US-20070232621-A1 | Linear dicationic terphenyls and their aza analogues as antiparasitic agents | GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. | 2007-10-04 | — | — | US | disclosed |
| US-20060293328-A1 | Linear dicationic terphenyls and their aza analogues as antiparasitic agents | TIDWELL RICHARD R | 2006-12-28 | — | — | US | disclosed |
| EP-1736466-A1 | Linear dicationic terphenyls and their aza analogues as antiparasitic agents | The University of North Carolina at Chapel Hill (US) | 2006-12-27 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070232621-A1 | Linear dicationic terphenyls and their aza analogues as antiparasitic agents | TPMT, TYMS, DDT | PRSS1 3549/4885PRSS3 3974/4885PRSS2 3504/4885 |
| US-20110257199-A1 | NOVEL TERARYL COMPOUNDS AS ANTIPARASITIC AGENTS | DDT, ZC3HAV1, MAVS | PRSS1 2702/4885PRSS3 3421/4885PRSS2 3225/4885 |
| US-20060293328-A1 | Linear dicationic terphenyls and their aza analogues as antiparasitic agents | TPMT, TYMS, DDT | PRSS1 3549/4885PRSS3 3974/4885PRSS2 3504/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.