Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 13/20 | 0.32 |
| ▸ | HTR2A | P28223 | 13/20 | 0.32 |
| ▸ | DRD3 | P35462 | 13/20 | 0.32 |
| ▸ | NAMPT | P43490 | 1/20 | 0.32 |
| ▸ | DRD4 | P21917 | 1/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.31 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3950772 | 0.95 | ALDH1A1 (0.36) | ALDH1A1DRD2DRD3NAMPTDRD4 | |
| SCHEMBL3950837 | 0.93 | ALDH1A1 (0.39) | ALDH1A1DRD2HTR2ADRD3SIGMAR1 | |
| SCHEMBL3949391 | 0.88 | ALDH1A1 (0.41) | ALDH1A1DRD2DRD3SIGMAR1 | |
| SCHEMBL4044981 | 0.82 | CHRM2 (0.36) | ALDH1A1DRD2HTR2ADRD3DRD4 | |
| SCHEMBL3950701 | 0.82 | NAMPT (0.36) | ALDH1A1DRD2HTR2ADRD3NAMPT | |
| SCHEMBL4176367 | 0.78 | DRD2 (0.34) | DRD2HTR2ADRD3 | |
| SCHEMBL3955895 | 0.77 | GNAO1 (0.40) | DRD2DRD3DRD4SIGMAR1 | |
| SCHEMBL3949734 | 0.77 | SIGMAR1 (0.37) | ALDH1A1DRD2DRD3DRD4SIGMAR1 | |
| SCHEMBL4044985 | 0.77 | DRD2 (0.32) | ALDH1A1DRD2HTR2ADRD3NAMPT | |
| SCHEMBL3949679 | 0.77 | CHRM5 (0.38) | ALDH1A1DRD2DRD3DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009024825-A1 | 2-PYRAZINYLBENZIMIDAZOLE DERIVATIVES AS RECEPTOR TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2009-02-26 | — | — | WO | disclosed |